KIAA0319基因累积得分对中国儿童阅读能力的影响:父母教育的调节和快速自动命名的中介作用。

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES
Jingjing Zhao, Qing Yang, Chen Cheng, Zhengjun Wang
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引用次数: 2

摘要

KIAA0319是一种经过充分研究的候选基因,已被证明与阅读能力和发展性阅读障碍有关。本研究探讨了KIAA0319是否通过与父母教育水平的交互作用影响阅读能力,以及快速自动命名(RAN)、语音意识和形态意识是否在KIAA0319与阅读能力的关系中起中介作用。共2284名中国小学三、六年级儿童参与本研究。汉字阅读准确性和单词阅读流畅性作为阅读能力的衡量标准。计算KIAA0319中13个snp的累积遗传风险评分(CGS)。结果表明,KIAA0319的CGS与父母教育水平对阅读流畅性有交互作用。交互效应表明,低CGS的KIAA0319个体比高CGS的个体在积极环境(较高的父母教育水平)中的阅读流畅性更好。此外,互作效应符合差异敏感性模型。多中介模型结果显示,RAN介导KIAA0319基因累积效应对阅读能力的影响。这些发现证明了KIAA0319是一个与环境因素相互作用影响阅读能力的风险易感基因,并证明了RAN作为基因与阅读关联之间的内表型的可靠性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cumulative genetic score of KIAA0319 affects reading ability in Chinese children: moderation by parental education and mediation by rapid automatized naming.

Cumulative genetic score of KIAA0319 affects reading ability in Chinese children: moderation by parental education and mediation by rapid automatized naming.

Cumulative genetic score of KIAA0319 affects reading ability in Chinese children: moderation by parental education and mediation by rapid automatized naming.

Cumulative genetic score of KIAA0319 affects reading ability in Chinese children: moderation by parental education and mediation by rapid automatized naming.

KIAA0319, a well-studied candidate gene, has been shown to be associated with reading ability and developmental dyslexia. In the present study, we investigated whether KIAA0319 affects reading ability by interacting with the parental education level and whether rapid automatized naming (RAN), phonological awareness and morphological awareness mediate the relationship between KIAA0319 and reading ability. A total of 2284 Chinese children from primary school grades 3 and 6 participated in this study. Chinese character reading accuracy and word reading fluency were used as measures of reading abilities. The cumulative genetic risk score (CGS) of 13 SNPs in KIAA0319 was calculated. Results revealed interaction effect between CGS of KIAA0319 and parental education level on reading fluency. The interaction effect suggested that individuals with a low CGS of KIAA0319 were better at reading fluency in a positive environment (higher parental educational level) than individuals with a high CGS. Moreover, the interaction effect coincided with the differential susceptibility model. The results of the multiple mediator model revealed that RAN mediates the impact of the genetic cumulative effect of KIAA0319 on reading abilities. These findings provide evidence that KIAA0319 is a risk vulnerability gene that interacts with environmental factor to impact reading abilities and demonstrate the reliability of RAN as an endophenotype between genes and reading associations.

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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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