口腔健康是心血管疾病的一个可改变的风险因素。

IF 7.3 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Serena Altamura , Rita Del Pinto , Davide Pietropaoli , Claudio Ferri
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引用次数: 0

摘要

心血管疾病(CVD)是全球发病率和死亡率的主要原因,具有较高的社会经济负担。越来越多的证据支持与牙周病(PD)心血管风险增加的令人信服的联系,牙周病是一组广泛存在、使人衰弱且代价高昂的支持牙齿的组织的失调性复发-缓解炎症性疾病。在此,我们汇集了关于心血管疾病和帕金森病之间联系的最佳可用证据,以回顾最近出现的将后者视为心血管疾病非传统风险因素的概念。我们重点研究了口腔微生态失调、炎症相关的分子和细胞机制,以及表观遗传学变化作为PD和CVD之间潜在的致病联系。还介绍了牙周治疗对心血管危险因素和疾病影响的现有证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oral health as a modifiable risk factor for cardiovascular diseases

Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality worldwide with a high socioeconomic burden. Increasing evidence supports a convincing connection with increased cardiovascular risk of periodontal diseases (PD), a group of widespread, debilitating, and costly dysbiotic relapsing-remitting inflammatory diseases of the tissues supporting the teeth. Herein, we ensembled the best available evidence on the connection between CVDs and PD to review the recently emerging concept of the latter as a non-traditional risk factor for CVDs. We focused on oral dysbiosis, inflammation-associated molecular and cellular mechanisms, and epigenetic changes as potential causative links between PD and CVDs. The available evidence on the effects of periodontal treatment on cardiovascular risk factors and diseases was also described.

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来源期刊
Trends in Cardiovascular Medicine
Trends in Cardiovascular Medicine 医学-心血管系统
CiteScore
18.70
自引率
2.20%
发文量
143
审稿时长
21 days
期刊介绍: Trends in Cardiovascular Medicine delivers comprehensive, state-of-the-art reviews of scientific advancements in cardiovascular medicine, penned and scrutinized by internationally renowned experts. The articles provide authoritative insights into various topics, encompassing basic mechanisms, diagnosis, treatment, and prognosis of heart and blood vessel disorders, catering to clinicians and basic scientists alike. The journal covers a wide spectrum of cardiology, offering profound insights into aspects ranging from arrhythmias to vasculopathies.
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