Soo Young Lee, Jaram Lee, Hyeong-Min Park, Chang Hyun Kim, Hyeong Rok Kim
{"title":"术前免疫营养对结肠癌患者粪便微生物群的影响:一项随机对照试验的二次分析。","authors":"Soo Young Lee, Jaram Lee, Hyeong-Min Park, Chang Hyun Kim, Hyeong Rok Kim","doi":"10.4162/nrp.2023.17.3.475","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/objectives: </strong>This study aimed to evaluate the effect of preoperative immunonutrition on the composition of fecal microbiota following a colon cancer surgery.</p><p><strong>Materials/methods: </strong>This study was a secondary analysis of a randomized controlled trial assessing the impact of preoperative immunonutrition on the postoperative outcomes of colon cancer surgery. Patients with primary colon cancer were enrolled and randomly assigned to receive additional preoperative immunonutrition or a normal diet alone. Oral nutritional supplementation (400 mL/day) with arginine and ω-3 fatty acids were administered to patients in the immunonutrition group for 7 days prior to surgery. Thirty-two fecal samples were collected from 16 patients in each group, and the composition of fecal microbiota was compared between the 2 groups.</p><p><strong>Results: </strong>At the phylum level, no significant difference was observed in the composition of microbiota between the 2 groups (<i>Firmicutes</i>, 69.1% vs. 67.5%, <i>P</i> = 0.624; <i>Bacteroidetes</i>, 19.3% vs. 18.1%, <i>P</i> = 0.663; <i>Actinobacteria</i>, 6.7% vs. 10.6%, <i>P</i> = 0.080). The <i>Firmicutes</i>/<i>Bacteroidetes</i> ratio (4.43 ± 2.32 vs. 4.55 ± 2.51, <i>P</i> = 0.897) was also similar between the 2 groups. At the genus level, the proportions of beneficial bacteria such as <i>Faecalibacterium</i> spp. (8.1% vs. 6.4%, <i>P</i> = 0.328) and <i>Prevotella</i> spp. (6.9% vs. 4.8%, <i>P</i> = 0.331) were higher, while that of <i>Clostridium</i> spp. was lower (0.5% vs. 1.2%, <i>P</i> = 0.121) in the immunonutrition group, but the difference was not significant.</p><p><strong>Conclusions: </strong>Immunonutrition showed no significant association with the composition of fecal microbiota. The relationship between immunonutrition and the fecal microbiota should be investigated further in large-scale studies.</p>","PeriodicalId":19232,"journal":{"name":"Nutrition Research and Practice","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/c0/nrp-17-475.PMC10232208.pdf","citationCount":"0","resultStr":"{\"title\":\"Effect of preoperative immunonutrition on fecal microbiota in colon cancer patients: a secondary analysis of a randomized controlled trial.\",\"authors\":\"Soo Young Lee, Jaram Lee, Hyeong-Min Park, Chang Hyun Kim, Hyeong Rok Kim\",\"doi\":\"10.4162/nrp.2023.17.3.475\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/objectives: </strong>This study aimed to evaluate the effect of preoperative immunonutrition on the composition of fecal microbiota following a colon cancer surgery.</p><p><strong>Materials/methods: </strong>This study was a secondary analysis of a randomized controlled trial assessing the impact of preoperative immunonutrition on the postoperative outcomes of colon cancer surgery. Patients with primary colon cancer were enrolled and randomly assigned to receive additional preoperative immunonutrition or a normal diet alone. Oral nutritional supplementation (400 mL/day) with arginine and ω-3 fatty acids were administered to patients in the immunonutrition group for 7 days prior to surgery. Thirty-two fecal samples were collected from 16 patients in each group, and the composition of fecal microbiota was compared between the 2 groups.</p><p><strong>Results: </strong>At the phylum level, no significant difference was observed in the composition of microbiota between the 2 groups (<i>Firmicutes</i>, 69.1% vs. 67.5%, <i>P</i> = 0.624; <i>Bacteroidetes</i>, 19.3% vs. 18.1%, <i>P</i> = 0.663; <i>Actinobacteria</i>, 6.7% vs. 10.6%, <i>P</i> = 0.080). The <i>Firmicutes</i>/<i>Bacteroidetes</i> ratio (4.43 ± 2.32 vs. 4.55 ± 2.51, <i>P</i> = 0.897) was also similar between the 2 groups. At the genus level, the proportions of beneficial bacteria such as <i>Faecalibacterium</i> spp. (8.1% vs. 6.4%, <i>P</i> = 0.328) and <i>Prevotella</i> spp. (6.9% vs. 4.8%, <i>P</i> = 0.331) were higher, while that of <i>Clostridium</i> spp. was lower (0.5% vs. 1.2%, <i>P</i> = 0.121) in the immunonutrition group, but the difference was not significant.</p><p><strong>Conclusions: </strong>Immunonutrition showed no significant association with the composition of fecal microbiota. 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引用次数: 0
摘要
背景/目的:本研究旨在评估术前免疫营养对结肠癌手术后粪便微生物群组成的影响。材料/方法:本研究是一项评估术前免疫营养对结肠癌手术后预后影响的随机对照试验的二次分析。原发性结肠癌患者被纳入并随机分配接受额外的术前免疫营养或单独的正常饮食。免疫营养组患者术前7天口服精氨酸和ω-3脂肪酸营养补充400ml /d。每组16例患者采集32份粪便标本,比较两组患者粪便菌群组成。结果:在门水平上,两组菌群组成差异无统计学意义(厚壁菌门,69.1% vs. 67.5%, P = 0.624;拟杆菌门,19.3% vs. 18.1%, P = 0.663;放线菌,6.7% vs. 10.6%, P = 0.080)。厚壁菌门/拟杆菌门比值(4.43±2.32比4.55±2.51,P = 0.897)在两组间也相似。在属水平上,免疫营养组有益菌的比例较高,粪杆菌(8.1%比6.4%,P = 0.328)和普雷沃氏菌(6.9%比4.8%,P = 0.331),梭状芽胞杆菌(0.5%比1.2%,P = 0.121),但差异不显著。结论:免疫营养与粪便微生物群组成无显著相关性。免疫营养与粪便微生物群之间的关系有待于进一步的大规模研究。
Effect of preoperative immunonutrition on fecal microbiota in colon cancer patients: a secondary analysis of a randomized controlled trial.
Background/objectives: This study aimed to evaluate the effect of preoperative immunonutrition on the composition of fecal microbiota following a colon cancer surgery.
Materials/methods: This study was a secondary analysis of a randomized controlled trial assessing the impact of preoperative immunonutrition on the postoperative outcomes of colon cancer surgery. Patients with primary colon cancer were enrolled and randomly assigned to receive additional preoperative immunonutrition or a normal diet alone. Oral nutritional supplementation (400 mL/day) with arginine and ω-3 fatty acids were administered to patients in the immunonutrition group for 7 days prior to surgery. Thirty-two fecal samples were collected from 16 patients in each group, and the composition of fecal microbiota was compared between the 2 groups.
Results: At the phylum level, no significant difference was observed in the composition of microbiota between the 2 groups (Firmicutes, 69.1% vs. 67.5%, P = 0.624; Bacteroidetes, 19.3% vs. 18.1%, P = 0.663; Actinobacteria, 6.7% vs. 10.6%, P = 0.080). The Firmicutes/Bacteroidetes ratio (4.43 ± 2.32 vs. 4.55 ± 2.51, P = 0.897) was also similar between the 2 groups. At the genus level, the proportions of beneficial bacteria such as Faecalibacterium spp. (8.1% vs. 6.4%, P = 0.328) and Prevotella spp. (6.9% vs. 4.8%, P = 0.331) were higher, while that of Clostridium spp. was lower (0.5% vs. 1.2%, P = 0.121) in the immunonutrition group, but the difference was not significant.
Conclusions: Immunonutrition showed no significant association with the composition of fecal microbiota. The relationship between immunonutrition and the fecal microbiota should be investigated further in large-scale studies.
期刊介绍:
Nutrition Research and Practice (NRP) is an official journal, jointly published by the Korean Nutrition Society and the Korean Society of Community Nutrition since 2007. The journal had been published quarterly at the initial stage and has been published bimonthly since 2010.
NRP aims to stimulate research and practice across diverse areas of human nutrition. The Journal publishes peer-reviewed original manuscripts on nutrition biochemistry and metabolism, community nutrition, nutrition and disease management, nutritional epidemiology, nutrition education, foodservice management in the following categories: Original Research Articles, Notes, Communications, and Reviews. Reviews will be received by the invitation of the editors only. Statements made and opinions expressed in the manuscripts published in this Journal represent the views of authors and do not necessarily reflect the opinion of the Societies.