红谷子在体外和体内上调脑源性神经营养因子水平。

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Kensuke Nakajima, Hayato Tomohiro, Shigeru Oiso
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引用次数: 0

摘要

大脑中脑源性神经营养因子(BDNF)的上调有助于预防和治疗抑郁症。BDNF可在各种外周组织和大脑中合成,并可通过血脑屏障到达大脑。因此,上调外周BDNF水平的食物可能有助于抑郁症的管理。我们之前利用能够产生和分泌BDNF的人肾腺癌ACHN细胞系,证实了白谷子上调BDNF的作用。然而,其他品种的谷子是否也能上调BDNF尚不清楚。在此,我们研究了红谷子(RFM)对体外和体内BDNF产生的影响。RFM甲醇提取物显著提高ACHN细胞培养液中BDNF水平,且高于wfm处理组。饲喂含20% RFM的标准日粮5周后,大鼠血清BDNF浓度显著高于对照组。此外,RFM甲醇提取物的丁醇部分显著增加ACHN细胞培养基中BDNF的水平,上调ACHN细胞中BDNF mRNA的表达。我们的研究结果表明,RFM有潜力作为一种具有bdnf诱导活性的食品材料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Red foxtail millet upregulates brain-derived neurotrophic factor levels in vitro and in vivo.

Upregulation of the brain-derived neurotrophic factor (BDNF) in the brain can help in the prevention and treatment of depression. BDNF is synthesized in various peripheral tissues, as well as in the brain, and can reach the brain via the blood-brain barrier. Therefore, foods that upregulate peripheral BDNF levels may aid in depression management. We previously showed the BDNF-upregulating effect of white foxtail millet (WFM) using the human renal adenocarcinoma ACHN cell line, capable of producing and secreting BDNF. However, whether other varieties of foxtail millet can also upregulate BDNF is unclear. Herein, we examined the effects of red foxtail millet (RFM) on BDNF production in vitro and in vivo. RFM methanol extracts significantly increased BDNF levels in the culture medium of ACHN cells, and the levels were higher than those with WFMtreatment. Serum BDNF concentrations in rats fed a standard diet containing 20% RFM for 5 weeks were significantly higher than those in the control. Furthermore, the butanol fraction of the RFM methanol extract significantly increased BDNF levels in the culture medium of ACHN cells and upregulated BDNF mRNA expression in ACHN cells. Our results suggest that RFM has potential as a food material with BDNF-inducing activity.

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来源期刊
Biomedical Research-tokyo
Biomedical Research-tokyo 医学-医学:研究与实验
CiteScore
2.40
自引率
0.00%
发文量
19
审稿时长
>12 weeks
期刊介绍: Biomedical Research is peer-reviewed International Research Journal . It was first launched in 1990 as a biannual English Journal and later became triannual. From 2008 it is published in Jan-Apr/ May-Aug/ Sep-Dec..
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