策略性地使用类器官和芯片器官作为仿生工具

IF 6.2 2区生物学 Q1 CELL BIOLOGY

Seminars in cell & developmental biology Pub Date : 2023-07-30 DOI:10.1016/j.semcdb.2022.09.010

Anderson K. Santos , Sérgio Scalzo , Raysa T.V. de Souza , Pedro H.G. Santana , Bruno L. Marques , Lucas F. Oliveira , Daniel M. Filho , Alexandre Hiroaki Kihara , Helton da Costa Santiago , Ricardo C. Parreira , Alexander Birbrair , Henning Ulrich , Rodrigo R. Resende

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引用次数: 4

摘要

类器官发育和芯片上的器官是基于分化干细胞的技术，在体内形成类似器官和组织的3D多细胞结构。因此，两者都可以战略性地用于疾病建模、药物筛选和宿主病原体研究。在这方面，这篇综述强调了该领域的重大进展，为类器官和芯片上的器官提供了最能模仿体内生理学的技术方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Strategic use of organoids and organs-on-chip as biomimetic tools

Organoid development and organ-on-a-chip are technologies based on differentiating stem cells, forming 3D multicellular structures resembling organs and tissues in vivo. Hence, both can be strategically used for disease modeling, drug screening, and host-pathogen studies. In this context, this review highlights the significant advancements in the area, providing technical approaches to organoids and organ-on-a-chip that best imitate in vivo physiology.

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来源期刊

Seminars in cell & developmental biology 生物-发育生物学

CiteScore

15.10

自引率

1.40%

发文量

310

审稿时长

9.1 weeks

期刊介绍： Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.