非活性基质Gla蛋白与2型糖尿病视网膜病变的关系。

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2023-01-05 eCollection Date: 2023-06-01 DOI:10.1007/s40200-022-01180-3

Hend Adel, Olfat Fawzy, Eman Mahmoud, Nesma Sayed Mohammed, Emad Gamil Khidr

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引用次数: 0

摘要

背景和目的：失活基质Gla蛋白（MGP）对2型糖尿病（T2DM）异位血管钙化的作用已得到广泛认可。然而，它在糖尿病微血管并发症中的作用仍然未知。该研究的目的是确定无活性MGP与糖尿病视网膜病变（DR）之间的任何关联。还探讨了其与胰岛素抵抗的关系。方法：该研究包括90名参与者、65名2型糖尿病患者（25名无DR，40名有DR）和25名健康对照。用ELISA法测定血清无活性MGP。还评估了HOMA-IR。结果：两组糖尿病患者的非活动性MGP均显著高于对照组（P P = 无活性MGP与HbA1c、HOMA-IR、LDL-C和甘油三酯呈正相关（P P = 0.008）和eGFR（P 结论：失活MGP与DR、胰岛素抵抗等代谢障碍危险因素有关。这些发现强调，不活跃的MGP可能是DR的发病机制、进化和进展的重要因素。

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Inactive matrix Gla protein in relation to diabetic retinopathy in type 2 diabetes.

Background and aims: The contribution of inactive Matrix Gla protein (MGP) to ectopic vascular calcification associated with type 2 diabetes mellitus (T2DM) is well recognized. However, its role in diabetic microvascular complications remains unknown. The study aim was to identify any association between inactive MGP and diabetic retinopathy (DR). Its relation to insulin resistance was also explored.

Methods: The study included 90 participants, 65 Type 2 diabetic patients (25 without DR and 40 with DR) and 25 healthy controls. Serum inactive MGP was measured using ELISA. HOMA-IR was also assessed.

Results: Inactive MGP was significantly higher in both diabetic groups compared to controls (P < 0.001), as well as in Type 2 diabetic patients with retinopathy compared to Type 2 diabetes without retinopathy (P = 0.002). Inactive MGP was positively correlated with HbA1c, HOMA-IR, LDL-C and triglycerides (P < 0.001), and negatively correlated with HDL-C (P = 0.008) and eGFR (P < 0.001). Logistic Regression Analysis showed that inactive MGP was one of the most associated factors with DR.

Conclusions: Inactive MGP was found to be related to DR, insulin resistance and other dysmetabolic risk factors. These findings highlight that inactive MGP may be a significant contributor to the pathogenesis, evolution, and progression of DR.

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.