叶酸和相关 B 族维生素对终生大脑健康的表观遗传效应:科学证实并将证据转化为改善健康的策略。

IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS
Nutrition Bulletin Pub Date : 2023-06-01 Epub Date: 2023-02-21 DOI:10.1111/nbu.12611
A Caffrey, Y Lamers, M M Murphy, N Letourneau, R E Irwin, K Pentieva, M Ward, A Tan, A Rojas-Gómez, L A Santos-Calderón, J Canals-Sans, B M Y Leung, R Bell, G F Giesbrecht, D Dewey, C J Field, M Kobor, C P Walsh, H McNulty
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引用次数: 0

摘要

叶酸和/或相互关联的 B 族维生素(B12、B6 和核黄素)状态不佳会扰乱一碳代谢,对生命早期的大脑发育和生命后期的大脑功能产生不利影响。人类研究表明,母亲在怀孕期间的叶酸状况与婴儿的认知发展有关,而最佳的 B 族维生素状况可能有助于防止日后出现认知功能障碍。解释这些关系的生物机制尚不清楚,但可能涉及与叶酸有关的 DNA 甲基化,以及与大脑发育和功能有关的表观遗传控制基因。在生命周期的关键阶段,有必要更好地了解这些 B 族维生素和表观基因组与大脑健康之间的关联机制,以支持循证健康改善策略。EpiBrain 项目是一个跨国合作项目,涉及英国、加拿大和西班牙的合作伙伴,该项目正在研究营养-表观基因组-大脑之间的关系,尤其关注叶酸相关的表观基因效应与大脑健康结果的关系。我们正在对生物样本库进行新的表观遗传学分析,这些样本来自现有的特征明确的队列以及在孕期和晚年进行的随机试验。膳食、营养生物标志物和表观遗传学数据将与儿童和老年人的脑部健康结果联系起来。此外,我们还将利用脑磁图(一种评估神经元功能的先进神经成像模式)研究 B 族维生素干预试验参与者的营养-表观基因组-大脑之间的关系。项目成果将使人们更好地了解叶酸和相关 B 族维生素对大脑健康的作用,以及其中涉及的表观遗传机制。预计研究成果将提供科学依据,支持在整个生命周期改善大脑健康的营养战略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epigenetic effects of folate and related B vitamins on brain health throughout life: Scientific substantiation and translation of the evidence for health improvement strategies.

Suboptimal status of folate and/or interrelated B vitamins (B12 , B6 and riboflavin) can perturb one-carbon metabolism and adversely affect brain development in early life and brain function in later life. Human studies show that maternal folate status during pregnancy is associated with cognitive development in the child, whilst optimal B vitamin status may help to prevent cognitive dysfunction in later life. The biological mechanisms explaining these relationships are not clear but may involve folate-related DNA methylation of epigenetically controlled genes related to brain development and function. A better understanding of the mechanisms linking these B vitamins and the epigenome with brain health at critical stages of the lifecycle is necessary to support evidence-based health improvement strategies. The EpiBrain project, a transnational collaboration involving partners in the United Kingdom, Canada and Spain, is investigating the nutrition-epigenome-brain relationship, particularly focussing on folate-related epigenetic effects in relation to brain health outcomes. We are conducting new epigenetics analysis on bio-banked samples from existing well-characterised cohorts and randomised trials conducted in pregnancy and later life. Dietary, nutrient biomarker and epigenetic data will be linked with brain outcomes in children and older adults. In addition, we will investigate the nutrition-epigenome-brain relationship in B vitamin intervention trial participants using magnetoencephalography, a state-of-the-art neuroimaging modality to assess neuronal functioning. The project outcomes will provide an improved understanding of the role of folate and related B vitamins in brain health, and the epigenetic mechanisms involved. The results are expected to provide scientific substantiation to support nutritional strategies for better brain health across the lifecycle.

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来源期刊
Nutrition Bulletin
Nutrition Bulletin NUTRITION & DIETETICS-
CiteScore
4.50
自引率
12.10%
发文量
58
期刊介绍: The Nutrition Bulletin provides accessible reviews at the cutting edge of research. Read by researchers and nutritionists working in universities and research institutes; public health nutritionists, dieticians and other health professionals; nutritionists, technologists and others in the food industry; those engaged in higher education including students; and journalists with an interest in nutrition.
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