糖尿病和肥胖在印度老年男性和女性肌肉骨骼疾病及其亚型易感性中的综合作用。

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM
Journal of Diabetes and Metabolic Disorders Pub Date : 2023-03-30 eCollection Date: 2023-06-01 DOI:10.1007/s40200-023-01211-7
Salmaan Ansari, Shazina Saeed
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引用次数: 0

摘要

背景和目的:在以后的生活中,糖尿病和肥胖会导致肌肉骨骼系统的变化,导致关节疼痛和无数其他肌肉骨骼疾病,如关节炎、骨质疏松症、风湿病、骨折等,导致包括疼痛和残疾在内的严重发病率。关于糖尿病和肥胖的共病如何增加老年人肌肉骨骼疾病的研究很少。因此,本研究使用了具有全国代表性的数据来研究糖尿病和肥胖与印度老年男性和女性肌肉骨骼疾病及其亚型(包括关节炎、骨质疏松症和风湿病)的相互作用。方法:数据取自2017-18年进行的第一波全国代表性调查印度纵向老龄化研究(LASI)。最终样本包括31464名60岁或以上的人。主要结果变量是任何列出的肌肉骨骼疾病,次要结果是其亚型,包括基于自我报告问题的关节炎、骨质疏松症和风湿病。基于体重和身高的人体测量指数(即标准截断值为30 kg/m2或以上的体重指数)的糖尿病和肥胖被认为是感兴趣的解释变量。Logistic回归用于评估糖尿病与肌肉骨骼疾病之间的关系。通过加法和乘法两种尺度进行相互作用分析。结果:与没有糖尿病的老年人相比,糖尿病患者的肌肉骨骼疾病及其亚型的患病率更高,尤其是老年女性的关节炎疾病。即使在控制了潜在因素后,糖尿病也与肌肉骨骼疾病及其亚型(包括关节炎和骨质疏松症)的风险显著相关。糖尿病和肥胖的组合与肌肉骨骼疾病显著正相关(aOR:4.14;p值 结论:这项研究表明,印度老年糖尿病患者患肌肉骨骼疾病的风险较高。这项研究的结果还表明,糖尿病和肥胖与肌肉骨骼疾病,特别是关节炎疾病之间存在相互关联。在治疗印度老年人糖尿病时,需要注意BMI水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The combined role of diabetes and obesity in susceptibility to musculoskeletal disorders and its subtypes in older men and women in India.

Background and aims: In later life, diabetes and obesity can cause a change in musculoskeletal systems that can lead to aching joints and a myriad of other musculoskeletal disorders such as arthritis, osteoporosis, rheumatism, bone fractures etc., resulting in significant morbidity including pain and disability. There is a paucity of research to know how comorbidity of diabetes and obesity increase musculoskeletal disorders among older people. Therefore, the present study used nationally representative data to examine the interaction of diabetes and obesity on musculoskeletal disorders and its subtypes including arthritis, osteoporosis, and rheumatism among older men and women in India.

Methods: Data were extracted from the first wave of the nationally representative survey Longitudinal Aging Study in India (LASI) conducted in 2017-18. The final sample includes 31,464 people aged 60 years or above. Primary outcome variable was any listed musculoskeletal disorders and secondary outcomes were its subtypes including arthritis, osteoporosis, and rheumatism based on self-reported questions. Diabetes and obesity based on anthropometric index of weight and height (i.e., body mass index (BMI) with a standard cut-off of 30 kg/m2 or over) were considered as explanatory variables of interest. Logistic regression was used to assess the relationship between diabetes and musculoskeletal disorders. Interaction analysis was performed by both additive and multiplicative scales.

Results: Comparing older people without diabetes, the prevalence of musculoskeletal disorders and its subtypes were higher among those with diabetes, particularly arthritis disorders in older women. Diabetes was significantly correlated with the risk of musculoskeletal disorders and its subtypes including arthritis and osteoporosis even after controlling potential factors. The combination of diabetes and obesity was significantly and positively associated with musculoskeletal disorders (aOR: 4.14; p-value < 0.0001; 95% CI: 1.96 to 8.74) and its subtype only arthritis (aOR: 4.36; p-value < 0.0001; 95% CI: 1.76 to 10.8) comparing to those without both the conditions. However, the association was strong for older women as compared to older men. Notwithstanding, multiplicative scale interaction showed statistically significant for musculoskeletal disorders and its three subtypes among older women, however it was not significant for osteoporosis and rheumatism disorders among older men. When we analyzed interaction on additive scale, we found it only for arthritis disorder among older women suggesting the risk from obesity (relative excess risk due to interaction (RERI): -0.83, 95% CI: -1.44 to -0.22, attributable proportion due to interaction (AP): -0.54, 95% CI: -1.05 to -0.03, synergy index (S): 0.39, 95% CI: 0.16 to 0.93) was additive to the risk from diabetes.

Conclusions: This study suggests an elevated risk of musculoskeletal disorders among Indian older adults with diabetes. The result of this study also suggests an interactive association of diabetes and obesity with musculoskeletal disorders, particularly with arthritis disorder. There is a need to pay attention to the BMI level while treating diabetes in Indian older population.

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来源期刊
Journal of Diabetes and Metabolic Disorders
Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine
CiteScore
4.80
自引率
3.60%
发文量
210
期刊介绍: Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.
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