与睡眠障碍相关的指数和共病精神障碍及精神药物。

IF 3.6 3区 医学 Q1 PSYCHIATRY
Ray M Merrill, McKay K Ashton, Emily Angell
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引用次数: 1

摘要

目的:精神障碍与睡眠障碍呈正相关。本研究将探讨共病性精神障碍的调节作用,以及所选择的精神药物在调整精神障碍后是否与睡眠障碍相关。方法:采用回顾性队列研究设计,采用Deseret Mutual Benefit Administrators (DMBA)的医疗索赔数据。从2016-2020年18-64岁的索赔文件中提取精神障碍、精神药物使用和人口统计数据。结果:大约11.7%的人提出了一项或多项睡眠障碍索赔[失眠(2.2%)和睡眠呼吸暂停(9.7%)]。选定精神障碍的发病率从精神分裂症的0.09%到焦虑症的8.4%不等。双相情感障碍或精神分裂症患者的失眠率高于其他精神障碍患者。双相情感障碍和抑郁症患者的睡眠呼吸暂停率更高。精神障碍与失眠和睡眠呼吸暂停之间存在显著的正相关,对于失眠来说更是如此,特别是如果他们有其他共病性精神障碍。除中枢神经系统兴奋剂以外的精神药物,主要是镇静剂(非巴比妥酸盐)和精神兴奋剂,可以解释焦虑、抑郁和双相情感障碍与失眠之间的积极联系。对睡眠障碍影响最大的精神药物是镇静剂(非巴比妥酸盐)和治疗失眠的精神兴奋剂,以及治疗睡眠呼吸暂停的精神兴奋剂和抗惊厥药。结论:精神障碍与失眠、睡眠呼吸暂停呈正相关。当存在多重精神疾病时,正相关更大。双相情感障碍和精神分裂症与失眠的关系最为密切,双相情感障碍和抑郁症与睡眠障碍的关系最为密切。除中枢神经系统兴奋剂以外的精神药物,主要是镇静剂(非巴比妥酸盐)和用于治疗焦虑、抑郁或双相情感障碍的精神兴奋剂与较高水平的失眠和睡眠呼吸暂停有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Sleep disorders related to index and comorbid mental disorders and psychotropic drugs.

Sleep disorders related to index and comorbid mental disorders and psychotropic drugs.

Sleep disorders related to index and comorbid mental disorders and psychotropic drugs.

Purpose: Mental disorders positively associate with sleep disorders. This study will explore the moderating influence of comorbid mental disorders and whether selected psychotropic drugs correlate with sleep disorders after adjusting for mental disorders.

Methods: A retrospective cohort study design was employed using medical claim data from the Deseret Mutual Benefit Administrators (DMBA). Mental disorders, psychotropic drug use, and demographic data were extracted from claim files for ages 18-64, years 2016-2020.

Results: Approximately 11.7% filed one or more claims for a sleep disorder [insomnia (2.2%) and sleep apnea (9.7%)]. Rates for selected mental disorders ranged from 0.09% for schizophrenia to 8.4% for anxiety. The rate of insomnia is greater in those with bipolar disorder or schizophrenia than in other mental disorders. The rate of sleep apnea is greater in those with bipolar disorder and depression. There is a significantly positive association between mental disorders and insomnia and sleep apnea, more so for insomnia, especially if they had other comorbid mental disorders. Psychotropic drugs other than CNS stimulants, primarily sedatives (non-barbiturate) and psychostimulants, explain much of the positive association between anxiety, depression, and bipolar disorder with insomnia. Psychotropic drugs with the largest effect on sleep disorders are sedatives (non-barbiturate) and psychostimulants for insomnia and psychostimulants and anticonvulsants for sleep apnea.

Conclusion: Mental disorders positively correlate with insomnia and sleep apnea. The positive association is greater when multiple mental illness exists. Bipolar disorder and schizophrenia are most strongly associated with insomnia, and bipolar disorder and depression are most strongly associated with sleep disorders. Psychotropic drugs other than CNS stimulants, primarily sedatives (non-barbiturate) and psychostimulants for treating anxiety, depression, or bipolar disorder are associated with higher levels of insomnia and sleep apnea.

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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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