Motomu Tanaka , Judith Thoma , Laura Poisa-Beiro , Patrick Wuchter , Volker Eckstein , Sascha Dietrich , Caroline Pabst , Carsten Müller-Tidow , Takao Ohta , Anthony D. Ho
{"title":"人造血干细胞和祖细胞的物理生物标志物","authors":"Motomu Tanaka , Judith Thoma , Laura Poisa-Beiro , Patrick Wuchter , Volker Eckstein , Sascha Dietrich , Caroline Pabst , Carsten Müller-Tidow , Takao Ohta , Anthony D. Ho","doi":"10.1016/j.cdev.2023.203845","DOIUrl":null,"url":null,"abstract":"<div><p>Adhesion of hematopoietic stem and progenitor cells (HSPCs) to the bone marrow niche plays critical roles in the maintenance of the most primitive HSPCs. The interactions of HSPC−niche interactions are clinically relevant in acute myeloid leukemia (AML), because (i) leukemia-initiating cells adhered to the marrow niche are protected from the cytotoxic effect by chemotherapy and (ii) mobilization of HSPCs from healthy donors' bone marrow is crucial for the effective stem cell transplantation. However, although many clinical agents have been developed for the HSPC mobilization, the effects caused by the extrinsic molecular cues were traditionally evaluated based on phenomenological observations. This review highlights the recent interdisciplinary challenges of hematologists, biophysicists and cell biologists towards the design of defined <em>in vitro</em> niche models and the development of physical biomarkers for quantitative indexing of differential effects of clinical agents on human HSPCs.</p></div>","PeriodicalId":36123,"journal":{"name":"Cells and Development","volume":"174 ","pages":"Article 203845"},"PeriodicalIF":3.9000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Physical biomarkers for human hematopoietic stem and progenitor cells\",\"authors\":\"Motomu Tanaka , Judith Thoma , Laura Poisa-Beiro , Patrick Wuchter , Volker Eckstein , Sascha Dietrich , Caroline Pabst , Carsten Müller-Tidow , Takao Ohta , Anthony D. Ho\",\"doi\":\"10.1016/j.cdev.2023.203845\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Adhesion of hematopoietic stem and progenitor cells (HSPCs) to the bone marrow niche plays critical roles in the maintenance of the most primitive HSPCs. The interactions of HSPC−niche interactions are clinically relevant in acute myeloid leukemia (AML), because (i) leukemia-initiating cells adhered to the marrow niche are protected from the cytotoxic effect by chemotherapy and (ii) mobilization of HSPCs from healthy donors' bone marrow is crucial for the effective stem cell transplantation. However, although many clinical agents have been developed for the HSPC mobilization, the effects caused by the extrinsic molecular cues were traditionally evaluated based on phenomenological observations. This review highlights the recent interdisciplinary challenges of hematologists, biophysicists and cell biologists towards the design of defined <em>in vitro</em> niche models and the development of physical biomarkers for quantitative indexing of differential effects of clinical agents on human HSPCs.</p></div>\",\"PeriodicalId\":36123,\"journal\":{\"name\":\"Cells and Development\",\"volume\":\"174 \",\"pages\":\"Article 203845\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cells and Development\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667290123000219\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cells and Development","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667290123000219","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Physical biomarkers for human hematopoietic stem and progenitor cells
Adhesion of hematopoietic stem and progenitor cells (HSPCs) to the bone marrow niche plays critical roles in the maintenance of the most primitive HSPCs. The interactions of HSPC−niche interactions are clinically relevant in acute myeloid leukemia (AML), because (i) leukemia-initiating cells adhered to the marrow niche are protected from the cytotoxic effect by chemotherapy and (ii) mobilization of HSPCs from healthy donors' bone marrow is crucial for the effective stem cell transplantation. However, although many clinical agents have been developed for the HSPC mobilization, the effects caused by the extrinsic molecular cues were traditionally evaluated based on phenomenological observations. This review highlights the recent interdisciplinary challenges of hematologists, biophysicists and cell biologists towards the design of defined in vitro niche models and the development of physical biomarkers for quantitative indexing of differential effects of clinical agents on human HSPCs.
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