TREM2:肿瘤微环境中的新参与者

IF 7.4 2区医学 Q1 IMMUNOLOGY

Seminars in Immunology Pub Date : 2023-05-01 DOI:10.1016/j.smim.2023.101739

Martina Molgora, Yizhou A. Liu, Marco Colonna, Marina Cella

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引用次数: 3

摘要

TREM2是一种髓细胞受体，在神经炎症和神经退行性疾病的背景下已被广泛描述。最近，TREM2成为肿瘤巨噬细胞功能的重要调节因子。TREM2缺乏或阻断在不同的小鼠模型中提供保护并促进对抗PD1的反应。在人类肿瘤中，表达TREM2的巨噬细胞存在于许多队列和肿瘤类型中，通常与免疫抑制和不良预后有关。在这里，我们提供了TREM2对肿瘤影响的概述，考虑到当前的文献，重点是小鼠模型和人类癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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TREM2: A new player in the tumor microenvironment

TREM2 is a myeloid cell receptor that has been extensively described in the context of neuroinflammation and neurodegenerative diseases. Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protection and promote the response to anti-PD1 in different murine models. In human tumors, TREM2-expressing macrophages are present in numerous cohorts and tumor types and are generally associated with immunosuppression and poor prognosis. Here, we provide an overview of the impact of TREM2 in tumors considering current literature, with a focus on both murine models and human cancer.

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来源期刊

Seminars in Immunology 医学-免疫学

CiteScore

11.40

自引率

1.30%

发文量

审稿时长

89 days

期刊介绍： Seminars in Immunology is a specialized review journal that serves as a valuable resource for scientists in the field of immunology. The journal's approach is thematic, with each issue dedicated to a specific topic of significant interest to immunologists. It covers a wide range of research areas, from the molecular and cellular foundations of the immune response to the potential for its manipulation, highlighting recent advancements in these areas. Each thematic issue is curated by a guest editor, who is recognized as an expert in the field internationally. The content of each issue typically includes six to eight authoritative invited reviews, which delve into various aspects of the chosen topic. The goal of these reviews is to provide a comprehensive, coherent, and engaging overview of the subject matter, ensuring that the information is presented in a timely manner to maintain its relevance. The journal's commitment to quality and timeliness is further supported by its inclusion in the Scopus database, which is a leading abstract and citation database of peer-reviewed literature. Being indexed in Scopus helps to ensure that the journal's content is accessible to a broad audience of researchers and professionals in immunology and related fields.