优化老化的大脑:痴呆预防伦理学的研究。

IF 3.3 Q2 GERIATRICS & GERONTOLOGY
M Andreoletti, C Lazzaroni, N Petersen, S Segawa, A Leibing, S Schicktanz, A Blasimme
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引用次数: 0

摘要

痴呆症最近经历了一次深刻的重新定义。长期以来被认为是一种不可预防的精神退化过程,目前的证据表明,至少三分之一的病例可以通过干预一系列特定因素来预防。从全球健康的角度来看,司法和公平问题在实施预防痴呆症方面显得尤为突出。因此,我们的项目通过特别关注痴呆症预防的情境方面,包含了有关痴呆症风险因素及其在国内和全球分布不均匀的新证据。这项研究的目的是优化老化的大脑?《痴呆症预防中的伦理问题》将剖析这种对痴呆症的新理解的伦理和临床假设,并分析这种关于痴呆症预防的新论述如何在三个国家:加拿大、德国和瑞士发挥作用。本研究采用多视角、比较、定性的方法,将利益相关者访谈与不同类型的重点民族志相结合,详细阐述了我们称之为“新型痴呆”的概念、伦理和社会方面。通过将阿尔茨海默病和痴呆症研究的范式转变置于当前老龄化文化和当代社会政策的背景下,我们旨在发起一场关于通常隐含的未解决的社会、伦理和政治影响以及医学理解和处理认知障碍的先决条件的辩论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Optimizing the Aging Brain: The BEAD Study on the Ethics of Dementia Prevention.

Dementia has lately undergone a profound reconceptualization. Long conceived of as an unpreventable process of mental deterioration, current evidence shows that it can be prevented in at least one in three cases intervening on a specified set of factors. Issues of justice and equity loom large on the implementation of dementia prevention, from a global health perspective. Our project thus embraces emerging evidence about dementia risk factors and their uneven distribution nationally and globally by specifically focusing on the situated aspects of dementia prevention. The aim of the BEAD study (Optimizing the Aging Brain? Situating Ethical Aspects in Dementia Prevention) is to dissect the ethical and clinical assumptions of this novel understanding of dementia, and to analyze how such new discourse on dementia prevention plays out in three countries: Canada, Germany and Switzerland. This study adopts a multi-perspective, comparative, qualitative approach, combining stakeholder interviews with different kinds of focused ethnographies, elaborating on conceptual, ethical, and social aspects of what we would like to call the "new dementia". By situating the paradigmatic shifts in Alzheimer's and dementia research within current aging cultures and contemporary social policies, we aim to initiate a debate about the often implicit unresolved social, ethical, and political implications and preconditions of the medical understanding and handling of cognitive disorders.

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来源期刊
Journal of Frailty & Aging
Journal of Frailty & Aging GERIATRICS & GERONTOLOGY-
CiteScore
5.90
自引率
7.70%
发文量
54
期刊介绍: The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons.          The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).
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