起源于鼻腔的淋巴上皮癌:病例报告及文献复习。

IF 0.4 Q4 OTORHINOLARYNGOLOGY
Hassan Alhazzani, Saleh Alabood, Ahmed Alhussien, Sahar Alsadah, Abdulrahman Alghulikah, Shuaa Asiri, Ibrahim Alarifi
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引用次数: 0

摘要

背景:鼻窦淋巴上皮癌(SNLEC)是一种罕见的肿瘤,占所有类型肿瘤的不到1%,约占头颈部肿瘤的3%。它可以影响鼻咽部,因为这个区域有丰富的淋巴组织。SNLEC的临床表现各不相同,从无症状到非特异性鼻窦症状不等。我们报告一例SNLEC,并回顾SNLEC的表现、诊断、治疗方案和结果的文献。案例演示。38岁男性,无医学纪录,到急诊科就诊,主诉鼻塞、右侧面部麻木、持续性右侧头痛、间歇性眼眶疼痛和前后鼻出血史。影像学显示右侧蝶窦有一破坏性肿块,延伸至不同的窦和颞下窝。活检证实了SNLEC的诊断,免疫组织化学检测EBV和CK8/18阳性。诱导化疗以三个周期的顺铂和吉西他滨开始,随后进行同步放化疗。结论:SNLEC是罕见的,来自世界各地的病例报道有限。它主要见于50岁至70岁之间的成年人,以男性为主。由于SNLEC与EBV有很强的相关性,因此可以通过影像学、免疫组织化学和EBV检测来诊断。由于病例有限,目前尚无治疗SNLEC的标准方法。然而,大多数用放射治疗的病例,以及用或不用其他方式治疗的病例在肿瘤不复发方面表现出良好的反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Lymphoepithelial Carcinoma Originated from the Sinonasal Cavity: Case Report and Literature Review.

Lymphoepithelial Carcinoma Originated from the Sinonasal Cavity: Case Report and Literature Review.

Lymphoepithelial Carcinoma Originated from the Sinonasal Cavity: Case Report and Literature Review.

Lymphoepithelial Carcinoma Originated from the Sinonasal Cavity: Case Report and Literature Review.

Background: Sinonasal lymphoepithelial carcinoma (SNLEC) is a rare neoplasm, representing less than 1% of all types of carcinomas and approximately 3% of head and neck tumors. It can affect the nasopharynx due to the rich lymphoid tissue present in this region. Clinical SNLEC presentation varies, ranging from asymptomatic to nonspecific sinonasal symptoms. We report a case of SNLEC and review the literature for SNLEC presentation, diagnosis, management options, and outcomes. Case Presentation. A 38-year-old male, medically free, presented to the emergency department complaining of nasal obstruction, right facial numbness, persistent right-sided headache, intermittent orbital pain, and a history of on/off epistaxis. Imaging showed a destructive mass in the right sphenoid sinus extending to different sinuses and infratemporal fossa. Biopsy confirmed the diagnosis of SNLEC, with immunohistochemistry being positive for Epstein-Barr virus (EBV) and CK8/18. Induction chemotherapy was started with three cycles of cisplatin and gemcitabine, followed by concurrent chemoradiation therapy.

Conclusion: SNLEC is rare, with limited reported cases from around the world. It is mostly seen in adults between their fifth and seventh decades with male predominance. SNLEC is diagnosed using imaging, immunohistochemistry, and EBV testing given its strong association with EBV. Owing to the limited cases, there is no standard approach to treating SNLEC. However, most cases managed with radiation and with and without other modalities showed an excellent response in terms of tumor nonrecurrence.

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来源期刊
Case Reports in Otolaryngology
Case Reports in Otolaryngology OTORHINOLARYNGOLOGY-
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审稿时长
13 weeks
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