sars - cov -2感染的活动性癌症患者在大流行的组粒期的高住院死亡率:来自德国CORONA研究的见解

IF 2 4区 医学 Q3 ONCOLOGY
Francis Maren Konermann, Nele Gessler, Peter Wohlmuth, Jürgen Behr, Johannes Feldhege, Christian Glöckner, Melanie A Gunawardene, Klaus R Herrlinger, Thomas Hölting, Ulrich-Frank Pape, Niels Reinmuth, Axel Stang, Sara Sheikhzadeh, Dirk Arnold, Claas Wesseler
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引用次数: 1

摘要

与非癌症患者相比,感染SARS-CoV-2的癌症患者预后更差,包括死亡率显着更高。然而,关于大流行欧米克隆阶段住院死亡率的数据有限。因此,本研究的目的是比较COVID-19大流行不同阶段癌症病史患者和活动性癌症患者的死亡率,重点关注当前备受关注的Omicron变异。方法:我们在德国的45家医院进行了一项多中心、观察性、流行病学队列研究。直到2022年7月20日,所有住院的成年SARS-CoV-2阳性患者都被纳入其中。主要终点是与癌症状态(癌症史和活动性癌症疾病)和SARS-CoV-2病毒类型相关的住院死亡率。结果:2020年3月11日至2022年7月20日,共纳入27490例成人SARS-CoV-2阳性患者。2578例(9.4%)患者确诊为癌症,其中1065例(41.3%)患者有癌症病史,1513例(58.7%)患者有活动性癌症。在27,490名患者中,总共有3,749人(13.6%)在住院期间死亡。在大流行的两个阶段,活动性癌症患者的死亡率明显高于无癌症诊断的患者(野生型到Delta型:OR 1.940 [1.646-2.285]);Omicron: 2.864[2.354-3.486])。在调整协变量后,在大流行的两个阶段,与其他组相比,感染SARS-CoV-2的活动性癌症患者的住院死亡率最高。结论:CORONA德国的研究表明,住院的活动性癌症患者在SARS-CoV-2感染期间死亡的风险很高。在Omicron期,有癌症病史的患者死亡率提高到接近非癌症患者的水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High In-Hospital Mortality in SARS-CoV-2-Infected Patients with Active Cancer Disease during Omicron Phase of the Pandemic: Insights from the CORONA Germany Study.

Introduction: SARS-CoV-2 infected patients with cancer have a worse outcome including a significant higher mortality, compared to non-cancer patients. However, limited data are available regarding in-hospital mortality during the Omicron phase of the pandemic. Therefore, the aim of the study was the comparison of mortality in patients with history of cancer and patients with active cancer disease during the different phases of the COVID-19 pandemic, focusing on the current Omicron variant of concern.

Methods: We conducted a multicenter, observational, epidemiological cohort study at 45 hospitals in Germany. Until July 20, 2022, all adult hospitalized SARS-CoV-2 positive patients were included. The primary endpoint was in-hospital mortality regarding cancer status (history of cancer and active cancer disease) and SARS-CoV-2 virus type.

Results: From March 11, 2020, to July 20, 2022, a total of 27,490 adult SARS-CoV-2 positive patients were included in the study. 2,578 patients (9.4%) had diagnosis of cancer, of whom 1,065 (41.3%) had history of cancer, whereas 1,513 (58.7%) had active cancer disease. Overall 3,749 out of the total of 27,490 patients (13.6%) died during the hospital stay. Patients with active cancer disease had a significantly higher mortality compared to patients without cancer diagnosis, in both phases of the pandemic (wild-type to Delta: OR 1.940 [1.646-2.285]); Omicron: 2.864 [2.354-3.486]). After adjustment to co-variables, SARS-CoV-2 infected patients with active cancer disease had the highest risk for in-hospital mortality compared to the other groups, in both phases of the pandemic.

Conclusion: The CORONA Germany study indicates that hospitalized patients with active cancer disease are at high risk of death during a SARS-CoV-2 infection. Mortality of patients with history of cancer improved to nearly the level of non-cancer patients during Omicron phase.

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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
84
期刊介绍: With the first issue in 2014, the journal ''Onkologie'' has changed its title to ''Oncology Research and Treatment''. By this change, publisher and editor set the scene for the further development of this interdisciplinary journal. The English title makes it clear that the articles are published in English – a logical step for the journal, which is listed in all relevant international databases. For excellent manuscripts, a ''Fast Track'' was introduced: The review is carried out within 2 weeks; after acceptance the papers are published online within 14 days and immediately released as ''Editor’s Choice'' to provide the authors with maximum visibility of their results. Interesting case reports are published in the section ''Novel Insights from Clinical Practice'' which clearly highlights the scientific advances which the report presents.
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