一个有趣的慢性髓性白血病病例，病情曲折。

IF 1.8 Q3 HEMATOLOGY

Hematology, Transfusion and Cell Therapy Pub Date : 2024-12-01 Epub Date: 2023-03-07 DOI:10.1016/j.htct.2023.02.001

Thulasi Raman Ramalingam, J Subramanian, I Nagarathinam, C Chandran, L Vaidhyanathan, J M Easow

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引用次数: 0

摘要

由于细胞遗传进化，慢性髓性白血病（CML）患者的Ph+细胞中会出现额外的细胞遗传异常（ACA）。但是分子进化和ACA的频率在CML患者的Ph细胞中要少得多，而且人们对其了解甚少。我们报告了一个有趣而罕见的Ph+ CML病例，他进展到B淋巴细胞危像，获得缓解，后来发展为Ph-急性髓性白血病（AML）， KMT2A基因重排，没有检测到BCR- ABL转录物。

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An interesting case of chronic myeloid leukemia with twists and turns.

Additional cytogenetic abnormalities (ACA) are known to crop up in Ph⁺ cells of chronic myeloid leukemia (CML) patients due to cytogenetic evolution. But the frequency of molecular evolution and ACA is much less in Ph^- cells of CML patients and is poorly understood. We report an interesting and rare case of Ph⁺ CML, who progressed to B lymphoblastic crisis, achieved remission, and later developed Ph^- acute myeloid leukemia (AML) with KMT2A gene rearrangement and no detectable BCR- ABL transcripts.

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