低热量饮食对银屑病合并非酒精性脂肪性肝病患者银屑病严重程度指数、甘油三酯、肝酶和生活质量的影响

IF 1.4 Q3 RHEUMATOLOGY
Reumatologia Pub Date : 2023-01-01 DOI:10.5114/reum/162995
Ali Mohamed Ali Ismail, Ahmad Elsayed Saad, Ramy Salama Draz
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引用次数: 4

摘要

简介:慢性斑块型银屑病是一种慢性炎症性皮肤病。肥胖合并症,包括非酒精性脂肪性肝病,在慢性斑块型银屑病患者中非常普遍。最近,减肥已成为一种强烈推荐的干预措施,以改善银屑病症状的严重程度、银屑病引起的慢性全身性炎症、银屑病相关心血管危险因素、生活质量和抗银屑病药物的疗效。本研究旨在评估12周低热量饮食干预对伴有慢性斑块和非酒精性脂肪肝的I级肥胖男性的天冬氨酸转氨酶、牛皮癣严重程度(通过牛皮癣面积和严重程度指数- PASI评估)、丙氨酸转氨酶、生活质量(通过皮肤病生活质量指数- DLQI评估)、甘油三酯、腰围(WC)和体重指数(BMI)的影响。材料和方法:60名年龄≥18岁的ⅰ类肥胖、慢性斑块性牛皮癣和非酒精性脂肪性肝病患者纳入研究。所有参与者被随机分为两组:第一组为低热量饮食组(30名男性接受免疫抑制药物,遵循低热量饮食,并通过每天15,000步的户外步行计划增加能量消耗,持续12周),第二组为对照组(30名男性只接受免疫抑制药物)。主要结果包括面积和严重程度指数的结果。体重、BMI、WC、实验室结果如甘油三酯、肝酶(丙氨酸转氨酶和天冬氨酸转氨酶)以及DLQI被认为是次要结局。结果:虽然对照组的测量变量没有显著改善,但低热量饮食组在所有测量变量上都有显著改善。结论:本研究的结果证实,12周的低热量饮食干预可以控制BMI,增加牛皮癣对药物的反应,改善生活质量。饮食干预可显著控制男性慢性斑块型银屑病和非酒精性脂肪肝患者肝酶(天冬氨酸和丙氨酸转氨酶)和甘油三酯升高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of low-calorie diet on psoriasis severity index, triglycerides, liver enzymes, and quality of life in psoriatic patients with non-alcoholic fatty liver disease.

Effect of low-calorie diet on psoriasis severity index, triglycerides, liver enzymes, and quality of life in psoriatic patients with non-alcoholic fatty liver disease.

Introduction: Chronic-plaque psoriasis is a chronic inflammatory dermatological disease. Obesity comorbidities, including non-alcoholic fatty liver disease, are highly prevalent in patients with chronic-plaque psoriasis. Recently, weight loss has been a highly recommended intervention to improve the severity of psoriatic symptoms, psoriasis-induced chronic systemic inflammation, psoriasis-associated cardiovascular risk factors, quality of life, and the efficacy of anti-psoriatic drugs. This study was designed to assess the effect of a 12-week low-calorie-diet intervention on aspartate transaminase, psoriasis severity (assessed via Psoriasis Area and Severity Index - PASI), alanine transaminase, quality of life (assessed via Dermatology Life Quality Index - DLQI), triglycerides, waist circumference (WC), and body mass index (BMI) in class I obese men with chronic-plaque and non-alcoholic fatty liver disease.

Material and methods: Sixty men with age ≥ 18 years with class I obesity and with chronic plaque psoriasis and non-alcoholic fatty liver disease were included in the study. All participants were randomly assigned to one of two groups: the first group as the low-calorie-diet group (30 men received immunosuppressive drugs, followed a low-calorie diet, and increased their energy expenditure through a daily 15,000-step outdoor walking program for 12 weeks) and the second as the control group (30 men received immunosuppressive drugs only). The primary outcome consisted of the results of the area and severity index. Weight, BMI, WC, laboratory results such as triglycerides, liver enzymes (alanine transaminase and aspartate transaminase) as well as DLQI were considered as secondary outcomes.

Results: While no significant improvements were achieved in the measured variables of the control group, the low-calorie-diet group demonstrated significant improvement in all the measured variables.

Conclusions: The results of the present study confirmed that 12-week low-calorie-diet intervention controls BMI, increases the response of psoriasis to pharmacological agents and improves the quality of life. Diet interventions significantly control the elevated hepatic enzymes (aspartate and alanine transaminases) and triglycerides in male patients with chronic-plaque psoriasis and non-alcoholic fatty liver disease.

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来源期刊
Reumatologia
Reumatologia Medicine-Rheumatology
CiteScore
2.70
自引率
0.00%
发文量
44
审稿时长
10 weeks
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