基因表达变化与人类对深部和大叶性脑出血的特异性外周免疫反应有关

IF 1.3 Q4 CLINICAL NEUROLOGY
Bodie Knepp , Bradley P. Ander , Glen C. Jickling , Heather Hull , Alan H. Yee , Kwan Ng , Fernando Rodriguez , Paulina Carmona-Mora , Hajar Amini , Xinhua Zhan , Marisa Hakoupian , Noor Alomar , Frank R. Sharp , Boryana Stamova
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引用次数: 1

摘要

外周免疫系统对脑出血的反应可能因脑出血部位的不同而不同。因此,我们研究了深部脑出血、大叶脑出血和血管危险因素匹配对照组的外周血mRNA表达(n = 59)。深部脑出血患者通常有高血压。部分大叶性脑出血患者存在脑淀粉样血管病(CAA)。比较深部脑出血和脑叶性脑出血的基因和基因网络。我们发现774个差异表达基因(DEGs)和2个共表达基因模块与深度ICH相关,441个差异表达基因(DEGs)和5个模块与大叶性ICH相关。途径富集显示了一些共同的免疫/炎症反应,包括自噬、T细胞受体、炎性体和神经炎症信号。Th2、干扰素、GP6和BEX2信号是深度ICH所特有的。坏死坏死信号,蛋白质泛素化,淀粉样蛋白加工和各种RNA加工术语是大叶性脑出血所特有的。在大叶性脑出血患者的血液中发现淀粉样蛋白加工途径,提示外周免疫细胞可能参与导致CAA血管周围/血管淀粉样蛋白的过程和/或参与其去除。本研究确定了深部脑出血和大叶脑出血中不同的外周血转录组结构,强调了在脑出血研究/临床试验中考虑位置的必要性,并提出了潜在的位置特异性治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Gene expression changes implicate specific peripheral immune responses to Deep and Lobar Intracerebral Hemorrhages in humans

Gene expression changes implicate specific peripheral immune responses to Deep and Lobar Intracerebral Hemorrhages in humans

Gene expression changes implicate specific peripheral immune responses to Deep and Lobar Intracerebral Hemorrhages in humans

Gene expression changes implicate specific peripheral immune responses to Deep and Lobar Intracerebral Hemorrhages in humans

The peripheral immune system response to Intracerebral Hemorrhage (ICH) may differ with ICH in different brain locations. Thus, we investigated peripheral blood mRNA expression of Deep ICH, Lobar ICH, and vascular risk factor-matched control subjects (n = 59). Deep ICH subjects usually had hypertension. Some Lobar ICH subjects had cerebral amyloid angiopathy (CAA). Genes and gene networks in Deep ICH and Lobar ICH were compared to controls. We found 774 differentially expressed genes (DEGs) and 2 co-expressed gene modules associated with Deep ICH, and 441 DEGs and 5 modules associated with Lobar ICH. Pathway enrichment showed some common immune/inflammatory responses between locations including Autophagy, T Cell Receptor, Inflammasome, and Neuroinflammation Signaling. Th2, Interferon, GP6, and BEX2 Signaling were unique to Deep ICH. Necroptosis Signaling, Protein Ubiquitination, Amyloid Processing, and various RNA Processing terms were unique to Lobar ICH. Finding amyloid processing pathways in blood of Lobar ICH patients suggests peripheral immune cells may participate in processes leading to perivascular/vascular amyloid in CAA vessels and/or are involved in its removal. This study identifies distinct peripheral blood transcriptome architectures in Deep and Lobar ICH, emphasizes the need for considering location in ICH studies/clinical trials, and presents potential location-specific treatment targets.

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来源期刊
Brain Hemorrhages
Brain Hemorrhages Medicine-Surgery
CiteScore
2.90
自引率
0.00%
发文量
52
审稿时长
22 days
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