钙通道在视网膜功能和疾病中的作用。

IF 5 2区医学 Q1 NEUROSCIENCES

Annual Review of Vision Science Pub Date : 2022-09-15 Epub Date: 2022-06-01 DOI:10.1146/annurev-vision-012121-111325

Brittany Williams, J Wesley Maddox, Amy Lee

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引用次数: 0

摘要

电压门控Ca2+（Cav）通道在调节基因转录、神经元兴奋性和神经递质释放方面发挥着关键作用。为了满足视觉信号的空间和时间需求，与神经系统其他区域的Cav通道相比，Cav通道在视网膜中表现出不同寻常的特性。在这篇文章中，我们回顾了目前关于视网膜中表达的Cav通道的特定亚型、它们的内在特性和调节形式，以及它们的失调如何导致视网膜疾病的概念。

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Calcium Channels in Retinal Function and Disease.

Voltage-gated Ca²⁺ (Ca_v) channels play pivotal roles in regulating gene transcription, neuronal excitability, and neurotransmitter release. To meet the spatial and temporal demands of visual signaling, Ca_v channels exhibit unusual properties in the retina compared to their counterparts in other areas of the nervous system. In this article, we review current concepts regarding the specific subtypes of Ca_v channels expressed in the retina, their intrinsic properties and forms of modulation, and how their dysregulation could lead to retinal disease.

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来源期刊

Annual Review of Vision Science Medicine-Ophthalmology

CiteScore

11.10

自引率

1.70%

发文量

期刊介绍： The Annual Review of Vision Science reviews progress in the visual sciences, a cross-cutting set of disciplines which intersect psychology, neuroscience, computer science, cell biology and genetics, and clinical medicine. The journal covers a broad range of topics and techniques, including optics, retina, central visual processing, visual perception, eye movements, visual development, vision models, computer vision, and the mechanisms of visual disease, dysfunction, and sight restoration. The study of vision is central to progress in many areas of science, and this new journal will explore and expose the connections that link it to biology, behavior, computation, engineering, and medicine.