炎症和骨关节炎。

IF 8.4 2区 医学 Q1 ALLERGY
Francesca Motta, Elisa Barone, Antonio Sica, Carlo Selmi
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引用次数: 37

摘要

骨关节炎是一种非常普遍的疾病,特别是在世界范围内65岁以上的受试者。虽然在过去,它被认为仅仅是软骨退化导致解剖和功能性关节损伤的结果,但近几十年来,滑膜、软骨和软骨下骨产生炎症介质,最终导致软骨损伤的观点更加动态。炎症被定义为在没有感染的情况下由内源性信号驱动的慢性、无菌、低度炎症状态,随着年龄的增长而发生。这种慢性状态与活性氧的产生和参与年龄相关疾病(如癌症、糖尿病、心血管和神经退行性疾病)发展的分子有关。炎症有助于骨关节炎的发展,其中包括先天和适应性免疫反应。全身和局部炎症细胞因子和衰老分子的升高促进软骨降解,来自受损关节的抗原通过炎性小体激活进一步引发炎症。B淋巴细胞和T淋巴细胞群也随着炎症和OA而改变,调节功能降低,因此暗示自我反应性是关节损伤的另一种机制。潜在致病途径的发现可能有助于确定治疗或预防骨关节炎的潜在治疗靶点。我们将对目前关于炎症在骨关节炎中的作用的文献进行全面评估,并讨论新兴的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Inflammaging and Osteoarthritis.

Inflammaging and Osteoarthritis.

Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age worldwide. While in the past it was considered a mere consequence of cartilage degradation leading to anatomical and functional joint impairment, in recent decades, there has been a more dynamic view with the synovium, the cartilage, and the subchondral bone producing inflammatory mediators which ultimately lead to cartilage damage. Inflammaging is defined as a chronic, sterile, low-grade inflammation state driven by endogenous signals in the absence of infections, occurring with aging. This chronic status is linked to the production of reactive oxygen species and molecules involved in the development of age-related disease such as cancer, diabetes, and cardiovascular and neurodegenerative diseases. Inflammaging contributes to osteoarthritis development where both the innate and the adaptive immune response are involved. Elevated systemic and local inflammatory cytokines and senescent molecules promote cartilage degradation, and antigens derived from damaged joints further trigger inflammation through inflammasome activation. B and T lymphocyte populations also change with inflammaging and OA, with reduced regulatory functions, thus implicating self-reactivity as an additional mechanism of joint damage. The discovery of the underlying pathogenic pathways may help to identify potential therapeutic targets for the management or the prevention of osteoarthritis. We will provide a comprehensive evaluation of the current literature on the role of inflammaging in osteoarthritis and discuss the emerging therapeutic strategies.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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