[Sysmex xn系列血液分析仪在疟疾快速诊断中的贡献:病例报告]。

IF 0.4 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY
Pauline Pitti, Françoise Tassin, Aurore Keutgens
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引用次数: 0

摘要

疟疾是一种潜在的严重疾病,特别是在非洲。在欧洲,大多数疟疾病例来自从流行地区返回的旅行者。如果不解决这种旅行的概念,非特异性症状可能不会提醒临床医生。然而,诊断和迅速开始治疗可防止疾病的严重形式演变,特别是在恶性疟原虫感染的情况下,这种情况可在24小时内危及生命。薄血涂片和厚血涂片镜检是诊断的主要工具,但一些自动化血液学分析仪已经证明了它们参与早期诊断的能力。我们描述了两个案例,说明了Sysmex XN-9100自动化系统对疟疾诊断的贡献。第一个临床病例描述了一个年轻人感染了大量的恶性疟原虫配子细胞。白细胞计数(WNR)和白细胞分化(WDF)散点图显示了一个额外的种群,对应于配子细胞。第二个病例集中在一名患有神经疟疾和高度恶性疟原虫寄生虫病的男子身上。寄生红细胞在网织红细胞散点图上形成不明显的双种群,位于成熟红细胞和网织红细胞的区分界限。散点图异常可以在几分钟内可视化,与薄涂片和厚涂片显微镜相比,它提供了疟疾诊断的预期,这需要大量的时间和专业知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Contribution of hematology analyzers (Sysmex XN-Series) in the rapid diagnosis of malaria: case reports].

Malaria is a potentially severe disease, particularly in Africa. In Europe, the majority of malaria cases come from travelers returning from endemic areas. The non-specific symptomatology may not alert the clinician if this notion of travel is not addressed. However, diagnosis and rapid initiation of treatment prevent the evolution of severe forms of the disease, especially in the case of Plasmodium falciparum infection, which can be life-threatening within 24 hours. Thin and thick blood smears microscopy is the main tools for diagnosis, but some automated hematology analyzers have demonstrated their ability to participate in early diagnosis. We describe two cases illustrating the contribution of the Sysmex XN-9100 automated system for the diagnosis of malaria. The first clinical case described a young man infected with numerous Plasmodium falciparum gametocytes. WNR (white blood cell count) and WDF (white blood cell differenciation) scattergrams showed an additional population, corresponding to gametocytes. The second case focused on a man with neuromalaria and high Plasmodium falciparum parasitaemia. Parasitized red blood cells form an inconspicuous double population on the reticulocyte scattergram, located at the discrimination limit between mature red blood cells and reticulocytes. Scattergram abnormalities, which can be visualized in a few minutes, offer an anticipation of the diagnosis of malaria in comparison to thin and thick smears microscopy, that requiring considerable time and expertise.

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来源期刊
Annales de biologie clinique
Annales de biologie clinique 医学-医学:研究与实验
CiteScore
0.80
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Multidisciplinary information with direct relevance to everyday practice Annales de Biologie Clinique, the official journal of the French Society of Clinical Biology (SFBC), supports biologists in areas including continuing education, laboratory accreditation and technique validation. With original articles, abstracts and accounts of everyday practice, the journal provides details of advances in knowledge, techniques and equipment, as well as a forum for discussion open to the entire community.
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