慢性阻塞性肺病虚弱的患病率、轨迹和临床结果的系统回顾和荟萃分析。

IF 3.1 3区 医学 Q1 PRIMARY HEALTH CARE
Peter Hanlon, Xuetong Guo, Eveline McGhee, Jim Lewsey, David McAllister, Frances S Mair
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引用次数: 0

摘要

本系统性综述综合了慢性阻塞性肺病患者体弱的测量和患病率,以及体弱与不良健康后果之间的关联。我们在 Medline、Embase 和 Web of Science(2001 年 1 月 1 日至 2021 年 9 月 8 日)上检索了针对慢性阻塞性肺病成人患者的观察性研究,这些研究评估了虚弱的流行率、轨迹或与健康相关结果的关系。我们进行了叙述性综合分析和随机效应荟萃分析。我们发现有 53 项符合条件的研究使用了 11 种不同的虚弱测量方法。最常见的是虚弱表型(32 例)、虚弱指数(5 例)和 Kihon 核对表(4 例)。不同的虚弱定义、环境和年龄(2.6%-80.9%)对患病率的估计也不尽相同。虚弱与死亡率(5/7 项研究)、慢性阻塞性肺疾病恶化(7/11 项研究)、住院(3/4 项研究)、气流阻塞(11/14 项研究)、呼吸困难(15/16 项研究)、慢性阻塞性肺疾病严重程度(10/12 项研究)、生活质量下降(3/4 项研究)和残疾(1/1 项研究)相关。总之,体弱在慢性阻塞性肺病患者中很常见,与不良后果风险增加有关。积极识别虚弱状态有助于进行风险分层,并确定有针对性干预的候选者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Systematic review and meta-analysis of prevalence, trajectories, and clinical outcomes for frailty in COPD.

Systematic review and meta-analysis of prevalence, trajectories, and clinical outcomes for frailty in COPD.

This systematic review synthesised measurement and prevalence of frailty in COPD and associations between frailty and adverse health outcomes. We searched Medline, Embase and Web of Science (1 January 2001-8 September 2021) for observational studies in adults with COPD assessing frailty prevalence, trajectories, or association with health-related outcomes. We performed narrative synthesis and random-effects meta-analyses. We found 53 eligible studies using 11 different frailty measures. Most common were frailty phenotype (n = 32), frailty index (n = 5) and Kihon checklist (n = 4). Prevalence estimates varied by frailty definitions, setting, and age (2.6-80.9%). Frailty was associated with mortality (5/7 studies), COPD exacerbation (7/11), hospitalisation (3/4), airflow obstruction (11/14), dyspnoea (15/16), COPD severity (10/12), poorer quality of life (3/4) and disability (1/1). In conclusion, frailty is a common among people with COPD and associated with increased risk of adverse outcomes. Proactive identification of frailty may aid risk stratification and identify candidates for targeted intervention.

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来源期刊
NPJ Primary Care Respiratory Medicine
NPJ Primary Care Respiratory Medicine PRIMARY HEALTH CARE-RESPIRATORY SYSTEM
CiteScore
5.50
自引率
6.50%
发文量
49
审稿时长
10 weeks
期刊介绍: npj Primary Care Respiratory Medicine is an open access, online-only, multidisciplinary journal dedicated to publishing high-quality research in all areas of the primary care management of respiratory and respiratory-related allergic diseases. Papers published by the journal represent important advances of significance to specialists within the fields of primary care and respiratory medicine. We are particularly interested in receiving papers in relation to the following aspects of respiratory medicine, respiratory-related allergic diseases and tobacco control: epidemiology prevention clinical care service delivery and organisation of healthcare (including implementation science) global health.
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