{"title":"在印度儿童队列中,以汽化喷雾方式滴入一只眼和常规滴入另一只眼的Tropicamide和Phenylephrine滴眼液的散瞳效果比较。","authors":"P G Vinay, Sunayana Bhat, Meera Mary Mathews","doi":"10.4103/joco.joco_127_22","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To determine by serial measurements and compare the pupillary mydriasis effect of tropicamide and phenylephrine drops administered as a vaporized spray over closed lids in one eye and through conventional instillation of eye drops in the other eye in a pediatric cohort.</p><p><strong>Methods: </strong>This prospective study was conducted on healthy children aged 6-15 years. After visual assessment, investigator 1 examined the child for initial pupillary size. Investigator 2 instilled the drops in one eye and applied the spray to the other eye randomly, and the response of the child was noted using the Wong-Baker pain rating scale. The eyes receiving the spray and the eyes receiving drop instillation were considered as Groups 1 and 2, respectively. Subsequently, serial pupillary measurements were carried out every 10 min for up to 40 min by investigator 1. The patient compliance for the two methods of drug instillation was also compared.</p><p><strong>Results: </strong>The study comprised 80 eyes. At 40 min, both the groups showed no statistical difference in the mydriasis effect, with Group 1 showing 7.23 mm mydriasis and Group 2 showing 7.58 mm (<i>P</i> = 0.058). The analysis of the pain rating scale showed better compliance with the spray method of drug instillation, which was statistically significant (<i>P</i> = 0.044).</p><p><strong>Conclusions: </strong>Our study shows that spray application is a less invasive method for pupillary dilatation, which has better compliance and provides equally good dilatation as conventional methods. This study proves the efficacy of spray application in an Indian pediatric cohort.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/b6/JCO-34-448.PMC10170984.pdf","citationCount":"0","resultStr":"{\"title\":\"A Comparison of the Mydriatic Efficacy of Tropicamide and Phenylephrine Eye Drops Administered as a Vaporized Spray in One Eye and Conventional Drop Instillation in the Other Eye in an Indian Pediatric Cohort.\",\"authors\":\"P G Vinay, Sunayana Bhat, Meera Mary Mathews\",\"doi\":\"10.4103/joco.joco_127_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To determine by serial measurements and compare the pupillary mydriasis effect of tropicamide and phenylephrine drops administered as a vaporized spray over closed lids in one eye and through conventional instillation of eye drops in the other eye in a pediatric cohort.</p><p><strong>Methods: </strong>This prospective study was conducted on healthy children aged 6-15 years. After visual assessment, investigator 1 examined the child for initial pupillary size. Investigator 2 instilled the drops in one eye and applied the spray to the other eye randomly, and the response of the child was noted using the Wong-Baker pain rating scale. The eyes receiving the spray and the eyes receiving drop instillation were considered as Groups 1 and 2, respectively. Subsequently, serial pupillary measurements were carried out every 10 min for up to 40 min by investigator 1. The patient compliance for the two methods of drug instillation was also compared.</p><p><strong>Results: </strong>The study comprised 80 eyes. At 40 min, both the groups showed no statistical difference in the mydriasis effect, with Group 1 showing 7.23 mm mydriasis and Group 2 showing 7.58 mm (<i>P</i> = 0.058). The analysis of the pain rating scale showed better compliance with the spray method of drug instillation, which was statistically significant (<i>P</i> = 0.044).</p><p><strong>Conclusions: </strong>Our study shows that spray application is a less invasive method for pupillary dilatation, which has better compliance and provides equally good dilatation as conventional methods. 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引用次数: 0
摘要
目的:通过一系列测量来确定并比较托品酰胺和苯肾上腺素滴眼液的瞳孔散瞳效果,这两种滴眼液分别作为汽化喷雾剂在一只眼睛闭眼和通过常规滴眼液在另一只眼睛滴眼液。方法:本前瞻性研究以6-15岁健康儿童为研究对象。在视觉评估后,研究者1检查了儿童的初始瞳孔大小。研究者2随机将滴药滴入一只眼睛,将喷雾剂喷入另一只眼睛,并使用Wong-Baker疼痛评定量表记录儿童的反应。将雾化眼和滴注眼分别视为第1组和第2组。随后,研究者1每10分钟进行一次连续瞳孔测量,持续40分钟。比较两种给药方法的患者依从性。结果:该研究包括80只眼睛。40 min时,两组除丝效果差异无统计学意义,1组为7.23 mm, 2组为7.58 mm (P = 0.058)。疼痛评定量表分析显示,喷淋给药方法的依从性较好,差异有统计学意义(P = 0.044)。结论:我们的研究表明,喷雾应用是一种微创的瞳孔扩张方法,具有更好的依从性,并提供与传统方法一样好的扩张效果。本研究证明了喷雾应用在印度儿科队列中的有效性。
A Comparison of the Mydriatic Efficacy of Tropicamide and Phenylephrine Eye Drops Administered as a Vaporized Spray in One Eye and Conventional Drop Instillation in the Other Eye in an Indian Pediatric Cohort.
Purpose: To determine by serial measurements and compare the pupillary mydriasis effect of tropicamide and phenylephrine drops administered as a vaporized spray over closed lids in one eye and through conventional instillation of eye drops in the other eye in a pediatric cohort.
Methods: This prospective study was conducted on healthy children aged 6-15 years. After visual assessment, investigator 1 examined the child for initial pupillary size. Investigator 2 instilled the drops in one eye and applied the spray to the other eye randomly, and the response of the child was noted using the Wong-Baker pain rating scale. The eyes receiving the spray and the eyes receiving drop instillation were considered as Groups 1 and 2, respectively. Subsequently, serial pupillary measurements were carried out every 10 min for up to 40 min by investigator 1. The patient compliance for the two methods of drug instillation was also compared.
Results: The study comprised 80 eyes. At 40 min, both the groups showed no statistical difference in the mydriasis effect, with Group 1 showing 7.23 mm mydriasis and Group 2 showing 7.58 mm (P = 0.058). The analysis of the pain rating scale showed better compliance with the spray method of drug instillation, which was statistically significant (P = 0.044).
Conclusions: Our study shows that spray application is a less invasive method for pupillary dilatation, which has better compliance and provides equally good dilatation as conventional methods. This study proves the efficacy of spray application in an Indian pediatric cohort.
期刊介绍:
Peer Review under the responsibility of Iranian Society of Ophthalmology Journal of Current Ophthalmology, the official publication of the Iranian Society of Ophthalmology, is a peer-reviewed, open-access, scientific journal that welcomes high quality original articles related to vision science and all fields of ophthalmology. Journal of Current Ophthalmology is the continuum of Iranian Journal of Ophthalmology published since 1969.