反复暴露于冷压应激时唾液细胞因子的即时和延迟反应

IF 2.2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Neuroimmunomodulation Pub Date : 2023-01-01 Epub Date: 2023-03-14 DOI:10.1159/000529625
Mauro F Larra, Silvia Capellino, Elena Schwendich, Leon von Haugwitz, Jörg Reinders, Edmund Wascher
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引用次数: 0

摘要

简介人们日益认识到,过度压力是现代社会中许多疾病的重要诱因,而监测这种与压力相关的影响有助于预防疾病。唾液炎症标记物的测量正在成为一种很有前途的工具,它可以无创量化压力对日常生活中免疫过程的影响,从而在出现严重健康问题之前及早发现异常。然而,要确定唾液细胞因子对急性应激反应的时间尺度和决定因素,还需要更多的实验室对照研究:我们反复让参与者接受冷压应激试验(CPT)或对照程序,并测量了一系列唾液细胞因子以及主观、心血管和皮质醇应激反应。CPT 每 15 分钟重复一次,共进行 3 次,每次持续 3 分钟。在前两次暴露后立即采集唾液样本,并在第一次干预开始后的 60 分钟内,每隔 15 分钟采集一次唾液样本:结果:我们发现唾液中可检测到多种细胞因子。但是,特定的应激效应仅限于 IL-8 和 IL-6,它们分别在应激开始后立即或 15 分钟后下降。此外,在应激组中,IL-8 与皮质醇分泌量呈负相关,而在对照组中则没有。唾液中的TNFα和IFNγ也有显著增加,但这些影响在应激和对照条件下相似:讨论:我们的研究结果表明,特定的唾液细胞因子可能对CPT诱导的急性应激的直接效应敏感,同时也强调了采用控制程序从唾液细胞因子的无关变化中辨别应激效应的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immediate and Delayed Salivary Cytokine Responses during Repeated Exposures to Cold Pressor Stress.

Introduction: Excessive stress is increasingly recognized as an important trigger of many diseases prevalent in modern societies, and monitoring such stress-related effects could aid prevention. The measurement of salivary markers of inflammation is emerging as a promising tool to non-invasively quantify stress' effects on immune processes in everyday life and thereby detect early aberrations before the manifestation of serious health problems. However, more laboratory-controlled research is needed in order to establish the timescale and determinants of salivary cytokine responses to acute stress.

Methods: We repeatedly exposed participants to Cold Pressor Stress Test (CPT) or a control procedure and measured a wide array of salivary cytokines as well as subjective, cardiovascular, and cortisol stress reactions. CPT exposure was repeated every 15 min, 3 times in total, with a duration of 3 min each. Saliva was sampled immediately after the first two exposures as well as in 15-min intervals until 60 min after the onset of the first intervention.

Results: We found that many cytokines were detectable in saliva. Specific stress effects were limited to IL-8 and IL-6, however, which decreased immediately or 15 min after stress onset, respectively. Moreover, IL-8 was negatively correlated to cortisol output in the stress but not in the control group. Significant increases were also observed in salivary TNFα and IFNγ; however, these effects were similar under both stress and control conditions.

Discussion: Our results show that particular salivary cytokines may be sensitive to immediate effects of acute CPT-induced stress and also highlight the importance of employing control procedures to discern stress effects from unrelated variations in salivary cytokines.

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来源期刊
Neuroimmunomodulation
Neuroimmunomodulation 医学-免疫学
CiteScore
3.60
自引率
4.20%
发文量
35
审稿时长
>12 weeks
期刊介绍: The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.
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