二氧化钛纳米结构-一把双刃剑:它们在干细胞分化、癌症治疗及其毒性问题中的作用的最新进展

IF 3.6 3区 医学 Q3 NANOSCIENCE & NANOTECHNOLOGY
Saravanan Ramesh, Kavitha Govarthanan, Arunkumar Palaniappan
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引用次数: 0

摘要

二氧化钛(TiO2)纳米结构在化妆品、牙膏、药品、涂料、纸张、油墨、塑料、食品、纺织品等领域有着广泛的应用。近年来,它们也被发现在癌症治疗中作为干细胞分化剂和刺激反应性药物传递系统具有巨大的潜力。在这篇综述中,我们介绍了二氧化钛基纳米结构在上述应用中的一些最新进展。我们还介绍了这些纳米材料的毒性问题和毒性问题背后的机制的最新研究。本文综述了近年来基于二氧化钛的纳米结构在干细胞分化潜力、光动力和声动力能力、刺激反应性药物传递系统方面的研究进展,以及它们的毒性问题。我们相信这篇综述将有助于研究人员了解二氧化钛纳米结构在应用方面的最新进展,以及与二氧化钛纳米结构相关的一些毒性问题,这将有助于他们为未来的应用设计更好的纳米药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
TiO2 nanostructures - a double edged sword: current progress on their role in stem cells' differentiation, cancer therapy, and their toxicity issues.

Titanium dioxide (TiO2)-based nanostructures have wide applications in cosmetics, toothpastes, pharmaceuticals, coatings, papers, inks, plastics, food products, textiles, and many others. Recently, they have also been found to have huge potential as stem cells' differentiation agents as well as stimuli-responsive drug delivery systems in cancer therapy. In this review, we present some of the recent progress in the role of TiO2-based nanostructures toward the above-mentioned applications. We also present recent studies on the toxicity issues of these nanomaterials and the mechanisms behind the toxicity issues. We have reviewed the recent progress of TiO2-based nanostructures on their stem cells' differentiation potentials, their photo- and sono-dynamic capabilities, as stimuli-responsive drug delivery systems, and finally their toxicity issues with mechanistic understanding on the same. We believe that this review will help researchers be aware of the latest progress in the applications as well as few toxicity issues associated with TiO2-based nanostructures, which will help them design better nanomedicine for future applications.

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来源期刊
Nanotoxicology
Nanotoxicology 医学-毒理学
CiteScore
10.10
自引率
4.00%
发文量
45
审稿时长
3.5 months
期刊介绍: Nanotoxicology invites contributions addressing research relating to the potential for human and environmental exposure, hazard and risk associated with the use and development of nano-structured materials. In this context, the term nano-structured materials has a broad definition, including ‘materials with at least one dimension in the nanometer size range’. These nanomaterials range from nanoparticles and nanomedicines, to nano-surfaces of larger materials and composite materials. The range of nanomaterials in use and under development is extremely diverse, so this journal includes a range of materials generated for purposeful delivery into the body (food, medicines, diagnostics and prosthetics), to consumer products (e.g. paints, cosmetics, electronics and clothing), and particles designed for environmental applications (e.g. remediation). It is the nano-size range if these materials which unifies them and defines the scope of Nanotoxicology . While the term ‘toxicology’ indicates risk, the journal Nanotoxicology also aims to encompass studies that enhance safety during the production, use and disposal of nanomaterials. Well-controlled studies demonstrating a lack of exposure, hazard or risk associated with nanomaterials, or studies aiming to improve biocompatibility are welcomed and encouraged, as such studies will lead to an advancement of nanotechnology. Furthermore, many nanoparticles are developed with the intention to improve human health (e.g. antimicrobial agents), and again, such articles are encouraged. In order to promote quality, Nanotoxicology will prioritise publications that have demonstrated characterisation of the nanomaterials investigated.
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