压力的窗口:对CRHPVN神经元新角色的一瞥。

IF 29.9 1区医学 Q1 PHYSIOLOGY

Physiological reviews Pub Date : 2023-04-01 DOI:10.1152/physrev.00056.2021

Neilen P Rasiah, Spencer P Loewen, Jaideep S Bains

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引用次数: 1

摘要

下丘脑室旁核(CRHPVN)中的促肾上腺皮质激素释放激素细胞控制对应激的缓慢内分泌反应。这些细胞上的突触对急性应激非常敏感，利用局部信号在这个系统上留下持久的印记。此外，最近的研究表明，这些细胞在控制不同的应激和生存行为中也起着关键作用。在此，我们回顾了这些观察结果，并对CRHPVN神经元作为行为、生理和内分泌应激反应的综合和可延展性中枢的作用提供了一个视角。

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Windows into stress: a glimpse at emerging roles for CRH^PVN neurons.

The corticotropin-releasing hormone cells in the paraventricular nucleus of the hypothalamus (CRH^PVN) control the slow endocrine response to stress. The synapses on these cells are exquisitely sensitive to acute stress, leveraging local signals to leave a lasting imprint on this system. Additionally, recent work indicates that these cells also play key roles in the control of distinct stress and survival behaviors. Here we review these observations and provide a perspective on the role of CRH^PVN neurons as integrative and malleable hubs for behavioral, physiological, and endocrine responses to stress.

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来源期刊

Physiological reviews 医学-生理学

CiteScore

56.50

自引率

0.90%

发文量

期刊介绍： Physiological Reviews is a highly regarded journal that covers timely issues in physiological and biomedical sciences. It is targeted towards physiologists, neuroscientists, cell biologists, biophysicists, and clinicians with a special interest in pathophysiology. The journal has an ISSN of 0031-9333 for print and 1522-1210 for online versions. It has a unique publishing frequency where articles are published individually, but regular quarterly issues are also released in January, April, July, and October. The articles in this journal provide state-of-the-art and comprehensive coverage of various topics. They are valuable for teaching and research purposes as they offer interesting and clearly written updates on important new developments. Physiological Reviews holds a prominent position in the scientific community and consistently ranks as the most impactful journal in the field of physiology.