Joon Seok, Sung-Dong Cho, Seong Jun Seo, Su-Hyung Park
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引用次数: 0
摘要
记忆 T 细胞通常是在识别外来抗原后产生的，它能快速有效地抵御再感染。不过，也有报道称，有一种 "类似记忆 "的 T 细胞群，即虚拟记忆 T 细胞（TVM），可在没有外来抗原的情况下获得记忆表型。据报道，TVM 细胞与先天性细胞一样，在细菌或病毒感染的第一线防御中发挥作用，但它们在免疫相关疾病中的保护或病理作用在很大程度上还不为人所知。在这篇综述中，我们将讨论目前对 TVM 细胞的认识，重点是它们的独特特征、免疫学特性以及在各种免疫相关疾病（如感染和癌症）中的作用。
Memory T cells that mediate fast and effective protection against reinfections are usually generated upon recognition on foreign Ags. However, a "memory-like" T-cell population, termed virtual memory T (TVM) cells that acquire a memory phenotype in the absence of foreign Ag, has been reported. Although, like innate cells, TVM cells reportedly play a role in first-line defense to bacterial or viral infections, their protective or pathological roles in immune-related diseases are largely unknown. In this review, we discuss the current understanding of TVM cells, focusing on their distinct characteristics, immunological properties, and roles in various immune-related diseases, such as infections and cancers.
期刊介绍：
Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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