皮肤中T细胞的多样性:新的见解。

IF 4.3 4区 医学 Q2 IMMUNOLOGY
Natalija Novak, Leticia Tordesillas, Beatriz Cabanillas
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引用次数: 1

摘要

T细胞聚集在皮肤上,提供有效的免疫监视,抵抗外界的伤害,并维持组织的稳态。大多数皮肤T细胞是αβ T细胞,然而,γδ T细胞也存在,尽管频率低得多。在皮肤中可以发现不同的αβ T细胞亚群,如短命效应T细胞、中枢记忆T细胞、效应记忆T细胞和组织驻留记忆T细胞。它们的不同生物学、功能和位置为皮肤中的免疫反应提供了充足的光谱。Foxp3+记忆调节性T细胞在维持皮肤稳态中起关键作用,其失调与不同的皮肤病理有关。皮肤也含有非经典T细胞群,如γδ T细胞、NK T细胞和mr1限制性T细胞。在过去的几年里,它们在皮肤稳态和对病原体的反应中的作用已经得到了很好的确立,然而,也有越来越多的证据表明它们在介导过敏性皮肤炎症和促进对过敏原的敏化方面的作用。在这篇综述中,我们提供了关于不同的T细胞亚群的最新概述,这些T细胞亚群在皮肤中的作用,并特别关注它们在过敏性皮肤炎症中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diversity of T cells in the skin: Novel insights.

T cells populate the skin to provide an effective immunosurveillance against external insults and to maintain tissue homeostasis. Most cutaneous T cells are αβ T cells, however, γδ T cells also exist although in much lower frequency. Different subsets of αβ T cells can be found in the skin, such as short-lived effector T cells, central memory T cells, effector memory T cells, and tissue-resident memory T cells. Their differential biology, function, and location provide an ample spectrum of immune responses in the skin. Foxp3+ memory regulatory T cells have a pivotal role in maintaining homeostasis in the skin and their dysregulation has been linked with different skin pathologies. The skin also contains populations of non-classical T cells, such as γδ T cells, NK T cells, and MR1-restricted T cells. Their role in skin homeostasis and response to pathogens has been well established in the past years, however, there is also growing evidence of their role in mediating allergic skin inflammation and promoting sensitization to allergens. In this review, we provide an updated overview on the different subsets of T cells that populate the skin with a specific focus on their role in allergic skin inflammation.

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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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