粘胶菊对醋酸致大鼠溃疡性结肠炎的改善作用。

IF 1.6 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Mustafa Cellat, İbrahim Ozan Tekeli, Erdinç Türk, Tuba Aydin, Ahmet Uyar, Cafer Tayer İşler, İshak Gökçek, Muhammed Etyemez, Mehmet Güvenç
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引用次数: 0

摘要

增加的促炎细胞因子和氧化应激有助于溃疡性结肠炎(UC)的病理生理。粘菊是一种具有抗氧化和抗炎特性的植物。我们研究了粘多糖乙醇提取物对醋酸建立的实验性UC模型的影响。将大鼠分为四组,每组8只:第一组为对照组;2组,3%醋酸组;第3组,100 mg/kg磺胺吡啶+ 3%乙酸组;第4组,400 mg/kg .粘胶+ 3%醋酸。1 .粘胶和柳氮磺胺嘧啶灌胃,3%醋酸每直肠给药。我们发现粘菌处理降低了结肠丙二醛、肿瘤坏死因子-α、白细胞介素-1 β和核因子κ B水平;增加还原型谷胱甘肽、核因子红系2相关因子2、血红素加氧酶-1和kelch样ech相关蛋白1水平及谷胱甘肽过氧化物酶活性。1组结肠组织结构正常。4组结肠组织可见轻微炎性细胞浸润水肿,隐窝轻度糜烂。我们发现粘胶杆菌通过诱导结肠内Nrf-2/Keap-1/HO-1通路降低氧化应激和炎症,对UC具有保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inula viscosa ameliorates acetic acid induced ulcerative colitis in rats.

Increased pro-inflammatory cytokines and oxidative stress contribute to the pathophysiology of ulcerative colitis (UC). Inula viscosa is a plant with antioxidant and anti-inflammatory properties. We investigated the effect of an ethanolic extract of I. viscosa on an experimental UC model created using acetic acid. Rats were divided into four groups of eight: group 1, control; group 2, 3% acetic acid group; group 3, 100 mg/kg sulfasalazine + 3% acetic acid group; group 4, 400 mg/kg I. viscosa + 3% acetic acid. I. viscosa and sulfasalazine were administered by oral gavage and 3% acetic acid was administered per rectum. We found that I. viscosa treatment decreased colon malondialdehyde, tumor necrosis factor-α, interleukin-1 beta and nuclear factor kappa B levels; it increased reduced glutathione, nuclear factor erythroid 2-related factor 2, heme oxygenase-1 and kelch-like ECH-associated protein 1 levels and glutathione peroxidase enzyme activity. Group 1 colon exhibited normal histological structure. Slight inflammatory cell infiltration and edema and insignificant slight erosion in crypts were detected in colon tissues of group 4. We found that I. viscosa reduced oxidative stress and inflammation, which was protective against UC by inducing the Nrf-2/Keap-1/HO-1 pathway in the colon.

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来源期刊
Biotechnic & Histochemistry
Biotechnic & Histochemistry 生物-生物工程与应用微生物
CiteScore
3.40
自引率
6.20%
发文量
46
审稿时长
6-12 weeks
期刊介绍: Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.
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