{"title":"艾滋病相关神经认知障碍筛查：开发和验证用于南非临床环境的简略神经心理测试组合。","authors":"Georgina Spies, Melanie Deist, Sharain Suliman, Soraya Seedat","doi":"10.1037/neu0000872","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The HIV Neurobehavioral Research Center International Neurobehavioral Battery is a culturally valid battery sensitive to the neurocognitive (NC) effects of HIV-infection. However, its lengthy administration time makes the battery impractical in resource-limited settings, like South Africa, which are often faced with an overwhelming disease burden, a lack of neurological and neuropsychological (NP) expertise, and staff shortages. The present study therefore sought to develop an abbreviated version of the HNRC Battery and validate this battery in a sample of people with HIV (PWH) in South Africa.</p><p><strong>Objective: </strong>The present study therefore sought to develop an abbreviated version of the HNRC battery and validate this battery in a sample of people with HIV (PWH) in South Africa.</p><p><strong>Method: </strong>Six measures were selected based on the NC test performances of 103 HIV-positive and 135 HIV-negative South African adults. For the validation, a subgroup of 103 PWH completed the full version of the battery, while the other subgroup of 52 PWH completed only the abbreviated version. Deficit scores of each participant were calculated. These scores were used as the gold standard against which the abbreviated battery was compared.</p><p><strong>Results: </strong>There was a reduction of 81% in administration time when compared to the full version of the battery. The abbreviated battery demonstrated good sensitivity (75.0%) and excellent specificity (94.9%) when compared with the full version. The abbreviated battery showed good diagnostic accuracy in identifying NC impairment in an HIV-positive South African sample with a significant reduction in administration time, making it a more practical option in busy South African clinic settings.</p><p><strong>Conclusion: </strong>The results of this study may facilitate the growth of neuroAIDS research and aid initial identification of HIV-related NC impairment in resource-constrained settings. (PsycInfo Database Record (c) 2023 APA, all rights reserved).</p>","PeriodicalId":19205,"journal":{"name":"Neuropsychology","volume":"37 2","pages":"166-180"},"PeriodicalIF":2.6000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992844/pdf/","citationCount":"0","resultStr":"{\"title\":\"Screening for HIV-associated neurocognitive impairment: Development and validation of an abbreviated neuropsychological test battery for use in South African clinical settings.\",\"authors\":\"Georgina Spies, Melanie Deist, Sharain Suliman, Soraya Seedat\",\"doi\":\"10.1037/neu0000872\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The HIV Neurobehavioral Research Center International Neurobehavioral Battery is a culturally valid battery sensitive to the neurocognitive (NC) effects of HIV-infection. However, its lengthy administration time makes the battery impractical in resource-limited settings, like South Africa, which are often faced with an overwhelming disease burden, a lack of neurological and neuropsychological (NP) expertise, and staff shortages. The present study therefore sought to develop an abbreviated version of the HNRC Battery and validate this battery in a sample of people with HIV (PWH) in South Africa.</p><p><strong>Objective: </strong>The present study therefore sought to develop an abbreviated version of the HNRC battery and validate this battery in a sample of people with HIV (PWH) in South Africa.</p><p><strong>Method: </strong>Six measures were selected based on the NC test performances of 103 HIV-positive and 135 HIV-negative South African adults. For the validation, a subgroup of 103 PWH completed the full version of the battery, while the other subgroup of 52 PWH completed only the abbreviated version. Deficit scores of each participant were calculated. These scores were used as the gold standard against which the abbreviated battery was compared.</p><p><strong>Results: </strong>There was a reduction of 81% in administration time when compared to the full version of the battery. The abbreviated battery demonstrated good sensitivity (75.0%) and excellent specificity (94.9%) when compared with the full version. The abbreviated battery showed good diagnostic accuracy in identifying NC impairment in an HIV-positive South African sample with a significant reduction in administration time, making it a more practical option in busy South African clinic settings.</p><p><strong>Conclusion: </strong>The results of this study may facilitate the growth of neuroAIDS research and aid initial identification of HIV-related NC impairment in resource-constrained settings. 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引用次数: 0
摘要
背景：艾滋病病毒神经行为研究中心国际神经行为测验是一种对艾滋病病毒感染的神经认知（NC）影响敏感的文化有效测验。然而，该测验需要较长的施测时间，因此在南非等资源有限的国家并不实用，因为这些国家通常面临着巨大的疾病负担、神经学和神经心理学（NP）专业知识的缺乏以及人员短缺等问题。因此，本研究试图开发一种缩写版的 HNRC 测试，并在南非的艾滋病毒感染者（PWH）样本中对该测试进行验证：因此，本研究试图开发一种缩略版的 HNRC 测试工具，并在南非的艾滋病病毒感染者（PWH）样本中对该测试工具进行验证：方法：根据南非 103 名 HIV 阳性和 135 名 HIV 阴性成人的 NC 测试表现，选择了六项测量指标。为了进行验证，103 名艾滋病感染者中的一个分组完成了完整版的测试，而另一个由 52 名艾滋病感染者组成的分组只完成了简略版的测试。每个参与者的缺陷得分都被计算出来。这些分数被用作黄金标准，并与简易版电池进行比较：结果：与完整版电池相比，使用时间减少了 81%。与完整版相比，缩略版电池显示出良好的灵敏度（75.0%）和卓越的特异性（94.9%）。缩略版电池在识别艾滋病毒呈阳性的南非样本中的数控功能障碍方面显示出良好的诊断准确性，同时大大缩短了使用时间，使其在繁忙的南非诊所环境中成为更实用的选择：结论：本研究的结果可促进神经艾滋病研究的发展，并有助于在资源有限的环境中初步识别与艾滋病相关的数控损伤。(PsycInfo Database Record (c) 2023 APA, 版权所有）。
Screening for HIV-associated neurocognitive impairment: Development and validation of an abbreviated neuropsychological test battery for use in South African clinical settings.
Background: The HIV Neurobehavioral Research Center International Neurobehavioral Battery is a culturally valid battery sensitive to the neurocognitive (NC) effects of HIV-infection. However, its lengthy administration time makes the battery impractical in resource-limited settings, like South Africa, which are often faced with an overwhelming disease burden, a lack of neurological and neuropsychological (NP) expertise, and staff shortages. The present study therefore sought to develop an abbreviated version of the HNRC Battery and validate this battery in a sample of people with HIV (PWH) in South Africa.
Objective: The present study therefore sought to develop an abbreviated version of the HNRC battery and validate this battery in a sample of people with HIV (PWH) in South Africa.
Method: Six measures were selected based on the NC test performances of 103 HIV-positive and 135 HIV-negative South African adults. For the validation, a subgroup of 103 PWH completed the full version of the battery, while the other subgroup of 52 PWH completed only the abbreviated version. Deficit scores of each participant were calculated. These scores were used as the gold standard against which the abbreviated battery was compared.
Results: There was a reduction of 81% in administration time when compared to the full version of the battery. The abbreviated battery demonstrated good sensitivity (75.0%) and excellent specificity (94.9%) when compared with the full version. The abbreviated battery showed good diagnostic accuracy in identifying NC impairment in an HIV-positive South African sample with a significant reduction in administration time, making it a more practical option in busy South African clinic settings.
Conclusion: The results of this study may facilitate the growth of neuroAIDS research and aid initial identification of HIV-related NC impairment in resource-constrained settings. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
期刊介绍：
Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.
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