CO2激光治疗外阴硬化地衣的分子证据。

IF 1.2 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Ginekologia polska Pub Date : 2023-05-10 DOI:10.5603/GP.a2023.0044

Adrianna Marzec, Anita Olejek, Kamila Stopinska, Wojciech Cnota, Iwona Gabriel

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引用次数: 0

摘要

外阴硬化性地衣是一种慢性、难治性疾病，可反复发作并导致多种并发症。药物治疗的有限疗效指导了包括使用二氧化碳激光在内的新疗法的研究。在我们的研究中，我们重点研究了胶原蛋白和弹性蛋白基因的表达，以及热休克蛋白和p53的表达在2例接受CO₂激光治疗的外阴硬化苔藓患者。在两位患者中，我们观察到由一位经验丰富的妇科医生观察到的临床症状减轻，以及激光治疗前后基因表达的显着变化。

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The use of CO2 laser in vulvar lichen sclerosus treatment - molecular evidence.

Vulvar lichen sclerosus is chronic and difficult to treat disorder, which offer is recurrent and leads to multiple complications. The limited efficacy of pharmacologic treatment directed the search for new therapies including use of CO₂ laser. In our study we focused on collagen and elastin gene expression as well as heat shock proteins and p53 expression in two patients with vulvar lichen sclerosus who underwent CO₂ laser therapy. In both patients we observed decreased clinical symptoms observed by an experienced gynecologist as well as significant changes in gene expression before and after laser treatment.

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来源期刊

Ginekologia polska OBSTETRICS & GYNECOLOGY-

CiteScore

2.00

自引率

15.40%

发文量

317

审稿时长

4-8 weeks

期刊介绍： Ginekologia Polska’ is a monthly medical journal published in Polish and English language. ‘Ginekologia Polska’ will accept submissions relating to any aspect of gynaecology, obstetrics and areas directly related. ‘Ginekologia Polska’ publishes original contributions, comparative works, case studies, letters to the editor and many other categories of articles.