作为脂肪酸、类胡萝卜素和固醇的重要来源的蓟马:生物活性化合物的生物合成和现代生物技术。

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Critical Reviews in Biotechnology Pub Date : 2024-06-01 Epub Date: 2023-05-09 DOI:10.1080/07388551.2023.2196373
Yingjie Song, Xuewei Yang, Shuangfei Li, Yanqing Luo, Jo-Shu Chang, Zhangli Hu
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引用次数: 0

摘要

Thraustochytrids 是真核生物和海洋原生生物。由于其在生产有益健康的生物活性化合物(如脂肪酸、类胡萝卜素和固醇)方面的卓越和可持续应用,它们越来越被认为是一种前景广阔的饲料添加剂。此外,日益增长的需求使得通过工业菌株工程合理设计目标产品变得至关重要。在这篇综述中,根据蓟马的化学结构、特性和生理功能,对蓟马体内积累的生物活性化合物进行了全面评估。并对脂肪酸、类胡萝卜素和甾醇的代谢网络和生物合成途径进行了系统总结。此外,还回顾了基于胁迫的策略在蓟马中的应用,以探索提高特定产品产量的潜在方法。甲壳动物中脂肪酸、类胡萝卜素和固醇的生物合成之间存在内在联系,因为它们共享合成路线的某些分支和一些共同的中间底物。尽管之前的研究已经提出了经典的合成途径,但这些化合物在甲壳动物体内合成的代谢流程仍未被揭示。此外,有必要结合全息技术深入了解不同应激的机制和影响,从而为基因工程提供指导。虽然基因编辑技术可以在蛛网膜中实现有针对性的基因敲入和敲出,但仍需要高效的基因编辑技术。这篇重要综述将提供全面的信息,有助于提高蓟马特定生物活性物质的商业生产力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thraustochytrids as a promising source of fatty acids, carotenoids, and sterols: bioactive compound biosynthesis, and modern biotechnology.

Thraustochytrids are eukaryotes and obligate marine protists. They are increasingly considered to be a promising feed additive because of their superior and sustainable application in the production of health-benefiting bioactive compounds, such as fatty acids, carotenoids, and sterols. Moreover, the increasing demand makes it critical to rationally design the targeted products by engineering industrial strains. In this review, bioactive compounds accumulated in thraustochytrids were comprehensively evaluated according to their chemical structure, properties, and physiological function. Metabolic networks and biosynthetic pathways of fatty acids, carotenoids, and sterols were methodically summarized. Further, stress-based strategies used in thraustochytrids were reviewed to explore the potential methodologies for enhancing specific product yields. There are internal relationships between the biosynthesis of fatty acids, carotenoids, and sterols in thraustochytrids since they share some branches of the synthetic routes with some intermediate substrates in common. Although there are classic synthesis pathways presented in the previous research, the metabolic flow of how these compounds are being synthesized in thraustochytrids still remains uncovered. Further, combined with omics technologies to deeply understand the mechanism and effects of different stresses is necessary, which could provide guidance for genetic engineering. While gene-editing technology has allowed targeted gene knock-in and knock-outs in thraustochytrids, efficient gene editing is still required. This critical review will provide comprehensive information to benefit boosting the commercial productivity of specific bioactive substances by thraustochytrids.

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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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