{"title":"家族性高胆固醇血症的血清对氧磷酶活性。","authors":"Kazuhiko Kotani, Naoki Sakane, Alejandro Gugliucci","doi":"10.5114/amsad/160952","DOIUrl":null,"url":null,"abstract":"Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-bound esterase that protects low-density lipoprotein (LDL) and HDL from oxidative stress [1]. Low PON1 activity in the circulation is generally associated with increased risk for the development of atherosclerosis and cardiovascular disease [1]. While PON1 is a promiscuous enzyme, displaying esterase and lactonase activities","PeriodicalId":8317,"journal":{"name":"Archives of Medical Sciences. Atherosclerotic Diseases","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/d8/AMS-AD-8-160952.PMC10161786.pdf","citationCount":"0","resultStr":"{\"title\":\"Serum paraoxonase activity in familial hypercholesterolaemia.\",\"authors\":\"Kazuhiko Kotani, Naoki Sakane, Alejandro Gugliucci\",\"doi\":\"10.5114/amsad/160952\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-bound esterase that protects low-density lipoprotein (LDL) and HDL from oxidative stress [1]. Low PON1 activity in the circulation is generally associated with increased risk for the development of atherosclerosis and cardiovascular disease [1]. While PON1 is a promiscuous enzyme, displaying esterase and lactonase activities\",\"PeriodicalId\":8317,\"journal\":{\"name\":\"Archives of Medical Sciences. Atherosclerotic Diseases\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/d8/AMS-AD-8-160952.PMC10161786.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Medical Sciences. Atherosclerotic Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/amsad/160952\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Medical Sciences. Atherosclerotic Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/amsad/160952","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Serum paraoxonase activity in familial hypercholesterolaemia.
Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-bound esterase that protects low-density lipoprotein (LDL) and HDL from oxidative stress [1]. Low PON1 activity in the circulation is generally associated with increased risk for the development of atherosclerosis and cardiovascular disease [1]. While PON1 is a promiscuous enzyme, displaying esterase and lactonase activities
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