表观遗传调控因子ASXL2:结构、功能及其在疾病中的预测价值

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.2174/1389203724666221208103516

Mengru Li, Lijun Xu, Rui Zhang, Chunming Dong

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引用次数: 0

摘要

ASXL2作为一种转录调控因子，是肿瘤检测的研究热点。ASXL2蛋白的异常表达主要与恶性血液病和心脏病有关。为了进一步探索ASXL2在疾病中的预测价值，我们综述了ASXL2蛋白的结构和功能、翻译后修饰机制以及ASXL2蛋白的表达在不同疾病发病中的作用，为今后治疗的发展提供理论依据和支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Epigenetic Regulator ASXL2: Structure, Function and its Predictive Value in Diseases.

ASXL2, as a transcription regulator, is a research hotspot for tumor detection. The aberrant expression of ASXL2 protein has been mainly implicated in malignant hematological and heart diseases. To further explore the predictive value of ASXL2 in diseases, we reviewed the structure and function of ASXL2 protein, the post-translational modification mechanism, and the expression of ASXL2 protein in the pathogenesis of different diseases to provide a theoretical basis and support for the development of future treatments.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.