杏仁核表达生长抑素的神经元向下丘脑和脑干的靶向特异性投射。

IF 2.8 4区 心理学 Q1 BEHAVIORAL SCIENCES
Jane J Bartonjo, Robert F Lundy
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引用次数: 4

摘要

杏仁核中央核(CeA/Sst)的生长抑素神经元可以被解析为投射到孤立束核(NST)或臂旁核(PBN)的亚群。我们最近表明,CeA/Sst-to-NST神经元的抑制增加了通常令人厌恶的味觉刺激,奎宁HCl (QHCl)的摄入。由于CeA能支配其他前脑区域,如向NST发送轴突投射的外侧下丘脑(LH),因此对QHCl摄入的影响可能部分是CeA调节LH- NST神经元的结果。为了解决这些问题,本研究调查了CeA/Sst-to-NST神经元是否与CeA/Sst-to-LH神经元不同。为了比较起见,另外的实验评估了CeA/Sst-to-PBN神经元对LH的发散性神经支配。在Sst-cre小鼠中,将两种不同的逆行转运的flox病毒注射到NST和同侧LH或PBN和同侧LH。结果表明,90%或更多的逆行标记的CeA/Sst神经元投射到LH、NST或PBN。投射到这些不同区域的不同CeA/Sst神经元群体表明,就突触目标和可能的功能而言,这是一个高度异质的群体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Target-specific projections of amygdala somatostatin-expressing neurons to the hypothalamus and brainstem.

Target-specific projections of amygdala somatostatin-expressing neurons to the hypothalamus and brainstem.

Target-specific projections of amygdala somatostatin-expressing neurons to the hypothalamus and brainstem.

Somatostatin neurons in the central nucleus of the amygdala (CeA/Sst) can be parsed into subpopulations that project either to the nucleus of the solitary tract (NST) or parabrachial nucleus (PBN). We have shown recently that inhibition of CeA/Sst-to-NST neurons increased the ingestion of a normally aversive taste stimulus, quinine HCl (QHCl). Because the CeA innervates other forebrain areas such as the lateral hypothalamus (LH) that also sends axonal projections to the NST, the effects on QHCl intake could be, in part, the result of CeA modulation of LH-to-NST neurons. To address these issues, the present study investigated whether CeA/Sst-to-NST neurons are distinct from CeA/Sst-to-LH neurons. For comparison purposes, additional experiments assessed divergent innervation of the LH by CeA/Sst-to-PBN neurons. In Sst-cre mice, two different retrograde transported flox viruses were injected into the NST and the ipsilateral LH or PBN and ipsilateral LH. The results showed that 90% or more of retrograde-labeled CeA/Sst neurons project either to the LH, NST, or PBN. Separate populations of CeA/Sst neurons projecting to these different regions suggest a highly heterogeneous population in terms of synaptic target and likely function.

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来源期刊
Chemical Senses
Chemical Senses 医学-行为科学
CiteScore
8.60
自引率
2.90%
发文量
25
审稿时长
1 months
期刊介绍: Chemical Senses publishes original research and review papers on all aspects of chemoreception in both humans and animals. An important part of the journal''s coverage is devoted to techniques and the development and application of new methods for investigating chemoreception and chemosensory structures.
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