{"title":"小脑梗死的广泛症状变异性及其与脑桥梗死的比较","authors":"Toralf Brüning, Tamara Beyrich, Mohamed Al-Khaled","doi":"10.1016/j.ensci.2023.100459","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and aim</h3><p>Cerebellar infarction (CI) is a serious cerebrovascular disease that may present with non-focal neurological deficits, leading to delay of clinical recognition and treatment. The aim of this study is to investigate the variability of symptoms, diagnostic outcomes and early prognosis in patients with cerebellar infarction compared with pontine infarction (PI).</p></div><div><h3>Methods</h3><p>Between 2012 and 2014, a total of 79 patients (68 ± 14 years, female sex 42%, median NIHSS score: 5) with CI (43) and PI (36) were included and analyzed.</p></div><div><h3>Results</h3><p>CI patients were admitted to emergency department one hour earlier compared with patients with PI. The most common symptoms in CI were dysarthria (67%), impaired coordination (61%), limb weakness (54%), dizziness/vertigo (49%), gait and stance uncertainty (42%), nausea or/and vomiting (42%), nystagmus (37%), dysphagia (30%) and headache (26%). Nineteen patients (44%) had symptomatic stenosis and two patients had vertebral artery dissection on duplex sonography and MR angiography.</p><p>Four patients (9%) received a systemic intravenous thrombolysis with rt-PA and three patients received mechanical thrombectomy.</p><p>Three months after the event, five patients (12%) had died and 15 (40) had disability with mRS (3–5).</p></div><div><h3>Conclusions</h3><p>Cerebellar infarction occurs with a high variability of symptoms and should be considered when non-focal symptoms are present.</p></div>","PeriodicalId":37974,"journal":{"name":"eNeurologicalSci","volume":"31 ","pages":"Article 100459"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121385/pdf/main.pdf","citationCount":"0","resultStr":"{\"title\":\"Wide symptom variability of cerebellar infarction and comparison with pons infarction\",\"authors\":\"Toralf Brüning, Tamara Beyrich, Mohamed Al-Khaled\",\"doi\":\"10.1016/j.ensci.2023.100459\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and aim</h3><p>Cerebellar infarction (CI) is a serious cerebrovascular disease that may present with non-focal neurological deficits, leading to delay of clinical recognition and treatment. The aim of this study is to investigate the variability of symptoms, diagnostic outcomes and early prognosis in patients with cerebellar infarction compared with pontine infarction (PI).</p></div><div><h3>Methods</h3><p>Between 2012 and 2014, a total of 79 patients (68 ± 14 years, female sex 42%, median NIHSS score: 5) with CI (43) and PI (36) were included and analyzed.</p></div><div><h3>Results</h3><p>CI patients were admitted to emergency department one hour earlier compared with patients with PI. The most common symptoms in CI were dysarthria (67%), impaired coordination (61%), limb weakness (54%), dizziness/vertigo (49%), gait and stance uncertainty (42%), nausea or/and vomiting (42%), nystagmus (37%), dysphagia (30%) and headache (26%). Nineteen patients (44%) had symptomatic stenosis and two patients had vertebral artery dissection on duplex sonography and MR angiography.</p><p>Four patients (9%) received a systemic intravenous thrombolysis with rt-PA and three patients received mechanical thrombectomy.</p><p>Three months after the event, five patients (12%) had died and 15 (40) had disability with mRS (3–5).</p></div><div><h3>Conclusions</h3><p>Cerebellar infarction occurs with a high variability of symptoms and should be considered when non-focal symptoms are present.</p></div>\",\"PeriodicalId\":37974,\"journal\":{\"name\":\"eNeurologicalSci\",\"volume\":\"31 \",\"pages\":\"Article 100459\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121385/pdf/main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"eNeurologicalSci\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405650223000175\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Neuroscience\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"eNeurologicalSci","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405650223000175","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Neuroscience","Score":null,"Total":0}
Wide symptom variability of cerebellar infarction and comparison with pons infarction
Background and aim
Cerebellar infarction (CI) is a serious cerebrovascular disease that may present with non-focal neurological deficits, leading to delay of clinical recognition and treatment. The aim of this study is to investigate the variability of symptoms, diagnostic outcomes and early prognosis in patients with cerebellar infarction compared with pontine infarction (PI).
Methods
Between 2012 and 2014, a total of 79 patients (68 ± 14 years, female sex 42%, median NIHSS score: 5) with CI (43) and PI (36) were included and analyzed.
Results
CI patients were admitted to emergency department one hour earlier compared with patients with PI. The most common symptoms in CI were dysarthria (67%), impaired coordination (61%), limb weakness (54%), dizziness/vertigo (49%), gait and stance uncertainty (42%), nausea or/and vomiting (42%), nystagmus (37%), dysphagia (30%) and headache (26%). Nineteen patients (44%) had symptomatic stenosis and two patients had vertebral artery dissection on duplex sonography and MR angiography.
Four patients (9%) received a systemic intravenous thrombolysis with rt-PA and three patients received mechanical thrombectomy.
Three months after the event, five patients (12%) had died and 15 (40) had disability with mRS (3–5).
Conclusions
Cerebellar infarction occurs with a high variability of symptoms and should be considered when non-focal symptoms are present.
期刊介绍：
eNeurologicalSci provides a medium for the prompt publication of original articles in neurology and neuroscience from around the world. eNS places special emphasis on articles that: 1) provide guidance to clinicians around the world (Best Practices, Global Neurology); 2) report cutting-edge science related to neurology (Basic and Translational Sciences); 3) educate readers about relevant and practical clinical outcomes in neurology (Outcomes Research); and 4) summarize or editorialize the current state of the literature (Reviews, Commentaries, and Editorials). eNS accepts most types of manuscripts for consideration including original research papers, short communications, reviews, book reviews, letters to the Editor, opinions and editorials. Topics considered will be from neurology-related fields that are of interest to practicing physicians around the world. Examples include neuromuscular diseases, demyelination, atrophies, dementia, neoplasms, infections, epilepsies, disturbances of consciousness, stroke and cerebral circulation, growth and development, plasticity and intermediary metabolism. The fields covered may include neuroanatomy, neurochemistry, neuroendocrinology, neuroepidemiology, neurogenetics, neuroimmunology, neuroophthalmology, neuropathology, neuropharmacology, neurophysiology, neuropsychology, neuroradiology, neurosurgery, neurooncology, neurotoxicology, restorative neurology, and tropical neurology.
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