接受门诊糖尿病护理的成年人多动症症状与2型糖尿病和心血管合并症的关系

IF 4.2 Q1 ENDOCRINOLOGY & METABOLISM
Ali Zare Dehnavi , Yanli Zhang-James , Dan Draytsel , Ben Carguello , Stephen V. Faraone , Ruth S. Weinstock
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引用次数: 0

摘要

背景注意缺陷/多动障碍(ADHD)症状与2型糖尿病(T2D)及其心血管结局之间的关系尚未得到充分的研究。方法采用成人自我报告量表V1.1(ASRS)扩展版,对来自上州医科大学乔斯林糖尿病中心的2986名T2D成人进行ADHD样症状、执行功能障碍和情绪控制评估。调查以电子方式发送,临床数据从电子病历中获得。分类变量关联采用皮尔逊卡方检验。当ASRS分数是因变量时,使用负二项回归校正与ASRS分数相关的人口统计学变量。结果155名(49.2%)被调查者的ASRS评分符合DSM-5标准;只有十名(3.6%)的受访者在他们的医疗记录中被ICD10诊断为多动症;43人(13.7%)在病史中被诊断为多动症,或者正在服用多动症患者使用的药物。与正常人群相比,T2D患者的多动症样症状水平更高。ASRS执行功能障碍分量表与总体心血管合并症之间存在适度的相关性(p=0.03)。然而,p值未能通过多次测试校正。然而,多动症样症状和与情绪控制相关的症状都与特定的心血管疾病、高血压或HbA1c、LDL胆固醇、甘油三酯、ALT、肌酸酐或eGFR无关。结论我们的研究结果表明,在三级糖尿病护理诊所就诊的T2D成年人有患多动症样疾病的风险,强调了在这一专业环境中筛查ADHD症状的重要性,并将未确诊的成年患者转诊为ADHD的进一步评估和治疗。需要进行更大规模的研究来阐明多动症样症状、执行功能障碍和情绪控制与糖尿病控制和合并症之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association of ADHD symptoms with type 2 diabetes and cardiovascular comorbidities in adults receiving outpatient diabetes care

Association of ADHD symptoms with type 2 diabetes and cardiovascular comorbidities in adults receiving outpatient diabetes care

Background

The relationship between attention-deficit/hyperactivity disorder (ADHD) symptoms and type 2 diabetes mellitus (T2D) and its cardiovascular outcomes have not been sufficiently studied.

Methods

2,986 adults with T2D from the Joslin Diabetes Center at Upstate Medical University were assessed for ADHD-like symptoms, executive dysfunction, and emotional control using the Adult Self-Report Scale V1.1 (ASRS) expanded version. Surveys were sent electronically, and clinical data were obtained from the electronic medical record. Pearson chi-square test was used for categorical variables association. When ASRS scores were the dependent variable, negative binomial regression correcting for demographic variables that were associated with the ASRS scores was used.

Results

155 (49.2%) of respondents met DSM-5 criteria for ADHD using the ASRS scores; Only ten (3.6%) of respondents had an ICD10 diagnosis of ADHD in their medical record; Forty-three (13.7%) had either a diagnosis of ADHD in the medical history or were taking medications used by people with ADHD. Higher levels of ADHD-like symptoms were found in patients with T2D compared with population norms. There was a modest association of the ASRS executive dysfunction subscale with overall cardiovascular comorbidities (p = 0.03). However, the p-value did not survive the multiple testing correction. Both ADHD-like symptoms and symptoms associated with emotional control, however, were not associated with specific cardiovascular diseases, hypertension, or with HbA1c, LDL-cholesterol, triglycerides, ALT, creatinine, or eGFR.

Conclusion

Our results suggest that adults with T2D attending a tertiary care diabetes clinic are at risk for having ADHD-like symptoms, highlighting the importance of screening for ADHD symptoms in this specialty setting and referring undiagnosed adult patients for further assessment and treatment of ADHD. Larger studies are needed to clarify the relationship between ADHD-like symptoms, executive dysfunction, and emotional control with diabetic control and comorbidities.

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来源期刊
CiteScore
6.10
自引率
0.00%
发文量
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审稿时长
16 weeks
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