{"title":"糖尿病肾病中的铁下垂：机制和治疗意义","authors":"Misganaw Asmamaw Mengstie , Mohammed Abdu Seid , Natnael Atnafu Gebeyehu , Getachew Asmare Adella , Gizchew Ambaw Kassie , Wubet Alebachew Bayih , Molalegn Mesele Gesese , Denekew Tenaw Anley , Sefineh Fenta Feleke , Melkamu Aderajew Zemene , Anteneh Mengist Dessie , Yenealem Solomon , Berihun Bantie , Tadesse Asmamaw Dejenie , Assefa Agegnehu Teshome , Endeshaw Chekol Abebe","doi":"10.1016/j.metop.2023.100243","DOIUrl":null,"url":null,"abstract":"<div><p>Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apoptotic, regulated cell death, characterized by the buildup of intracellular lipid peroxides to lethal levels. Although the role of programmed cell deaths like apoptosis, autophagy, and necroptosis in the pathogenesis of DN has been demonstrated, the implication of ferroptosis in DN was least interrogated. Hence, the main aim of this review was to discuss the current understanding of ferroptosis focusing on its potential mechanisms, its involvement in DN, and emerging therapeutic opportunities.</p></div>","PeriodicalId":94141,"journal":{"name":"Metabolism open","volume":"18 ","pages":"Article 100243"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/53/main.PMC10130620.pdf","citationCount":"2","resultStr":"{\"title\":\"Ferroptosis in diabetic nephropathy: Mechanisms and therapeutic implications\",\"authors\":\"Misganaw Asmamaw Mengstie , Mohammed Abdu Seid , Natnael Atnafu Gebeyehu , Getachew Asmare Adella , Gizchew Ambaw Kassie , Wubet Alebachew Bayih , Molalegn Mesele Gesese , Denekew Tenaw Anley , Sefineh Fenta Feleke , Melkamu Aderajew Zemene , Anteneh Mengist Dessie , Yenealem Solomon , Berihun Bantie , Tadesse Asmamaw Dejenie , Assefa Agegnehu Teshome , Endeshaw Chekol Abebe\",\"doi\":\"10.1016/j.metop.2023.100243\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apoptotic, regulated cell death, characterized by the buildup of intracellular lipid peroxides to lethal levels. Although the role of programmed cell deaths like apoptosis, autophagy, and necroptosis in the pathogenesis of DN has been demonstrated, the implication of ferroptosis in DN was least interrogated. Hence, the main aim of this review was to discuss the current understanding of ferroptosis focusing on its potential mechanisms, its involvement in DN, and emerging therapeutic opportunities.</p></div>\",\"PeriodicalId\":94141,\"journal\":{\"name\":\"Metabolism open\",\"volume\":\"18 \",\"pages\":\"Article 100243\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/53/main.PMC10130620.pdf\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Metabolism open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2589936823000154\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metabolism open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589936823000154","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Ferroptosis in diabetic nephropathy: Mechanisms and therapeutic implications
Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apoptotic, regulated cell death, characterized by the buildup of intracellular lipid peroxides to lethal levels. Although the role of programmed cell deaths like apoptosis, autophagy, and necroptosis in the pathogenesis of DN has been demonstrated, the implication of ferroptosis in DN was least interrogated. Hence, the main aim of this review was to discuss the current understanding of ferroptosis focusing on its potential mechanisms, its involvement in DN, and emerging therapeutic opportunities.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
