生物相关样品的飞行时间二次离子质谱分析的基本原理。I. 仪器和数据采集。

IF 1.6 4区医学 Q4 BIOPHYSICS

Biointerphases Pub Date : 2023-03-29 DOI:10.1116/6.0002477

Daniel J Graham, Lara J Gamble

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引用次数: 0

摘要

飞行时间二次离子质谱（ToF-SIMS）因其产生的化学特异性数据信息含量高而被广泛应用于工业和学术研究领域。现代 ToF-SIMS 仪器可生成高质量分辨率数据，并以光谱和图像（二维和三维）形式显示。这样就能确定分子在表面的分布情况，并获得其他方法无法获得的信息。有了这些详细的化学信息，如何正确获取和解释数据也是一个陡峭的学习曲线。本教程旨在帮助 ToF-SIMS 用户规划和收集 ToF-SIMS 数据。本系列的第二篇教程将介绍如何处理、显示和解释 ToF-SIMS 数据。

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Back to the basics of time-of-flight secondary ion mass spectrometry of bio-related samples. I. Instrumentation and data collection.

Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is used widely throughout industrial and academic research due to the high information content of the chemically specific data it produces. Modern ToF-SIMS instruments can generate high mass resolution data that can be displayed as spectra and images (2D and 3D). This enables determining the distribution of molecules across and into a surface and provides access to information not obtainable from other methods. With this detailed chemical information comes a steep learning curve in how to properly acquire and interpret the data. This Tutorial is aimed at helping ToF-SIMS users to plan for and collect ToF-SIMS data. The second Tutorial in this series will cover how to process, display, and interpret ToF-SIMS data.

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来源期刊

Biointerphases 生物-材料科学：生物材料

自引率

0.00%

发文量

期刊介绍： Biointerphases emphasizes quantitative characterization of biomaterials and biological interfaces. As an interdisciplinary journal, a strong foundation of chemistry, physics, biology, engineering, theory, and/or modelling is incorporated into originated articles, reviews, and opinionated essays. In addition to regular submissions, the journal regularly features In Focus sections, targeted on specific topics and edited by experts in the field. Biointerphases is an international journal with excellence in scientific peer-review. Biointerphases is indexed in PubMed and the Science Citation Index (Clarivate Analytics). Accepted papers appear online immediately after proof processing and are uploaded to key citation sources daily. The journal is based on a mixed subscription and open-access model: Typically, authors can publish without any page charges but if the authors wish to publish open access, they can do so for a modest fee. Topics include: bio-surface modification nano-bio interface protein-surface interactions cell-surface interactions in vivo and in vitro systems biofilms / biofouling biosensors / biodiagnostics bio on a chip coatings interface spectroscopy biotribology / biorheology molecular recognition ambient diagnostic methods interface modelling adhesion phenomena.