治疗小儿弓形虫病的嘧霉胺三维打印件：设计、药代动力学和抗弓形虫活性。

IF 5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Expert Opinion on Drug Delivery Pub Date : 2023-02-01 Epub Date: 2023-01-29 DOI:10.1080/17425247.2023.2169272

Ziyaur Rahman, Tahir Khuroo, Eman M Mohamed, Sathish Dharani, Canberk Kayalar, Mathew A Kuttolamadom, Lamba Omar Sangaré, Mansoor A Khan

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引用次数: 0

摘要

目的：本研究的重点是开发氨苄西林（PMT）的印片制剂：本研究的重点是开发嘧霉胺（PMT）的印片制剂：方法：通过筛选设计，改变激光扫描速度、Kollidon® VA 64、聚乙烯吡咯烷酮和崩解剂，研制出氨甲喋呤的小丸配方：结果：激光扫描速度、Kollidon® VA 和崩解剂对硬度、崩解时间和/或溶解度有显著的统计学影响（P 0.05）：结论：印片的临床表现与压缩片相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pyrimethamine 3D printlets for pediatric toxoplasmosis: design, pharmacokinetics, and anti-toxoplasma activity.

Objectives: The focus of the present research is to develop printlet formulations of pyrimethamine (PMT).

Methods: Printlets formulation of PMT were developed by screening design by varying laser scanning speed, Kollidon® VA 64, polyvinylpyrrolidone, and disintegrant.

Results: Laser scanning speed, Kollidon® VA, and disintegrant had statistically significant effect on hardness, disintegration time, and/or dissolution (p < 0.05). Dissolution was almost 100% in 30 min. X-ray powder diffraction indicated partial amorphous transformation of the crystalline drug. Pharmacokinetic and anti-toxoplasma activity profiles of the printlets and compressed tablets were superimposable with no statistical difference (p > 0.05).

Conclusion: Clinical performance of the printlets would be similar to the compressed tablets.

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来源期刊

Expert Opinion on Drug Delivery 医学-药学

CiteScore

11.10

自引率

3.00%

发文量

104

审稿时长

3 months

期刊介绍： Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.