反刍球菌:人类健康的朋友还是敌人?

IF 10.1 2区 生物学 Q1 MICROBIOLOGY
Emmanuelle H Crost, Erika Coletto, Andrew Bell, Nathalie Juge
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引用次数: 0

摘要

反刍球菌(Ruminococcus gnavus)于 1974 年首次被鉴定为健康人肠道中的一种严格厌氧菌,几十年来,对它的研究仅限于特定的酶或细菌素。随着元基因组学的出现,R. gnavus 与越来越多的肠道和肠道外疾病(从炎症性肠病到神经系统疾病)产生了正反两方面的联系。这重新激发了人们对 R. gnavus 适应肠道机制以及影响其与健康和疾病关系的分子介质的兴趣。自1990年以来,约有250篇文章引用了R. gnavus,其中94%是在过去10年中发表的。在这篇综述中,我们描述了R. gnavus的生物学特征、其在婴儿和成人肠道微生物群中的出现情况以及影响其在胃肠道定植的因素;我们还讨论了我们对其在宿主健康和疾病中的作用的认识现状。我们强调了知识方面的差距,并讨论了一种假设,即与肠道中 gnavus 相关的不同健康结果是菌株和生态位特异性的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Ruminococcus gnavus: friend or foe for human health.

Ruminococcus gnavus: friend or foe for human health.

Ruminococcus gnavus: friend or foe for human health.

Ruminococcus gnavus: friend or foe for human health.

Ruminococcus gnavus was first identified in 1974 as a strict anaerobe in the gut of healthy individuals, and for several decades, its study has been limited to specific enzymes or bacteriocins. With the advent of metagenomics, R. gnavus has been associated both positively and negatively with an increasing number of intestinal and extraintestinal diseases from inflammatory bowel diseases to neurological disorders. This prompted renewed interest in understanding the adaptation mechanisms of R. gnavus to the gut, and the molecular mediators affecting its association with health and disease. From ca. 250 publications citing R. gnavus since 1990, 94% were published in the last 10 years. In this review, we describe the biological characterization of R. gnavus, its occurrence in the infant and adult gut microbiota and the factors influencing its colonization of the gastrointestinal tract; we also discuss the current state of our knowledge on its role in host health and disease. We highlight gaps in knowledge and discuss the hypothesis that differential health outcomes associated with R. gnavus in the gut are strain and niche specific.

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来源期刊
FEMS microbiology reviews
FEMS microbiology reviews 生物-微生物学
CiteScore
17.50
自引率
0.90%
发文量
45
审稿时长
6-12 weeks
期刊介绍: Title: FEMS Microbiology Reviews Journal Focus: Publishes reviews covering all aspects of microbiology not recently surveyed Reviews topics of current interest Provides comprehensive, critical, and authoritative coverage Offers new perspectives and critical, detailed discussions of significant trends May contain speculative and selective elements Aimed at both specialists and general readers Reviews should be framed within the context of general microbiology and biology Submission Criteria: Manuscripts should not be unevaluated compilations of literature Lectures delivered at symposia must review the related field to be acceptable
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