纳米材料在脑出血治疗中的应用。

IF 6.7 1区工程技术 Q1 CELL & TISSUE ENGINEERING

Journal of Tissue Engineering Pub Date : 2023-01-01 DOI:10.1177/20417314231157004

Xiangyu Zhang, Suliman Khan, Ruixue Wei, Yan Zhang, Yang Liu, Voon Wee Yong, Mengzhou Xue

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引用次数: 1

摘要

脑出血(ICH)是由脑实质血管破裂引起的非创伤性出血，急性死亡率为30%-40%。目前，包括手术在内的现有治疗方案并不乐观，迫切需要新的方法。纳米技术以其独特的优势为非物质文化遗产研究提供了新的前景。本文就纳米材料在ICH中的应用作一综述。纳米材料不仅可以增强药物作为递送载体的治疗效果，而且还有助于脑出血后的几个方面，如抑制有害的神经炎症、抵抗氧化应激、减少细胞死亡和改善功能缺陷。

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Application of nanomaterials in the treatment of intracerebral hemorrhage.

Intracerebral hemorrhage (ICH) is a non-traumatic hemorrhage caused by the rupture of blood vessels in the brain parenchyma, with an acute mortality rate of 30%‒40%. Currently, available treatment options that include surgery are not promising, and new approaches are urgently needed. Nanotechnology offers new prospects in ICH because of its unique benefits. In this review, we summarize the applications of various nanomaterials in ICH. Nanomaterials not only enhance the therapeutic effects of drugs as delivery carriers but also contribute to several facets after ICH such as repressing detrimental neuroinflammation, resisting oxidative stress, reducing cell death, and improving functional deficits.

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来源期刊

Journal of Tissue Engineering Engineering-Biomedical Engineering

CiteScore

11.60

自引率

4.90%

发文量

审稿时长

12 weeks

期刊介绍： The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.