在TOF-MRA中实现脑动脉瘤自动检测:开放数据,弱标签和解剖学知识。

IF 2.7 4区 医学 Q2 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
Tommaso Di Noto, Guillaume Marie, Sebastien Tourbier, Yasser Alemán-Gómez, Oscar Esteban, Guillaume Saliou, Meritxell Bach Cuadra, Patric Hagmann, Jonas Richiardi
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引用次数: 7

摘要

随着深度学习(DL)的出现,飞行时间磁共振血管造影(TOF-MRA)中的脑动脉瘤检测得到了极大的改进。然而,有监督深度学习模型的性能严重依赖于标记样本的数量,而这些样本的获取成本非常高。在这里,我们提出了一个用于动脉瘤检测的深度学习模型,该模型克服了“弱”标签的问题:超大的注释,创建速度快得多。我们的弱标签生成速度是体素标签生成速度的四倍。此外,我们的模型通过只关注动脉瘤发生的可能位置来利用先前的解剖学知识。我们首先通过内部TOF-MRA数据集的交叉验证来训练和评估我们的模型,该数据集包括284名受试者(170名女性/ 127名健康对照/ 157名患有198个动脉瘤的患者)。在这个数据集上,我们的最佳模型达到了83%的灵敏度,每名患者的假阳性(FP)率为0.8。为了评估模型的普遍性,我们随后参与了一项利用TOF-MRA数据检测动脉瘤的挑战(93名患者,20名对照组,125个动脉瘤)。对于公众挑战,敏感性为68% (FP率= 2.5),在公开排行榜上排名第4 /18。我们发现动脉瘤破裂风险组(p = 0.75)、位置(p = 0.72)和大小(p = 0.15)之间的敏感性无显著差异。数据、代码和模型权重在许可许可下发布。我们证明了弱标签和解剖知识可以减轻昂贵的体素注释的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Towards Automated Brain Aneurysm Detection in TOF-MRA: Open Data, Weak Labels, and Anatomical Knowledge.

Towards Automated Brain Aneurysm Detection in TOF-MRA: Open Data, Weak Labels, and Anatomical Knowledge.

Towards Automated Brain Aneurysm Detection in TOF-MRA: Open Data, Weak Labels, and Anatomical Knowledge.

Towards Automated Brain Aneurysm Detection in TOF-MRA: Open Data, Weak Labels, and Anatomical Knowledge.

Brain aneurysm detection in Time-Of-Flight Magnetic Resonance Angiography (TOF-MRA) has undergone drastic improvements with the advent of Deep Learning (DL). However, performances of supervised DL models heavily rely on the quantity of labeled samples, which are extremely costly to obtain. Here, we present a DL model for aneurysm detection that overcomes the issue with "weak" labels: oversized annotations which are considerably faster to create. Our weak labels resulted to be four times faster to generate than their voxel-wise counterparts. In addition, our model leverages prior anatomical knowledge by focusing only on plausible locations for aneurysm occurrence. We first train and evaluate our model through cross-validation on an in-house TOF-MRA dataset comprising 284 subjects (170 females / 127 healthy controls / 157 patients with 198 aneurysms). On this dataset, our best model achieved a sensitivity of 83%, with False Positive (FP) rate of 0.8 per patient. To assess model generalizability, we then participated in a challenge for aneurysm detection with TOF-MRA data (93 patients, 20 controls, 125 aneurysms). On the public challenge, sensitivity was 68% (FP rate = 2.5), ranking 4th/18 on the open leaderboard. We found no significant difference in sensitivity between aneurysm risk-of-rupture groups (p = 0.75), locations (p = 0.72), or sizes (p = 0.15). Data, code and model weights are released under permissive licenses. We demonstrate that weak labels and anatomical knowledge can alleviate the necessity for prohibitively expensive voxel-wise annotations.

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来源期刊
Neuroinformatics
Neuroinformatics 医学-计算机:跨学科应用
CiteScore
6.00
自引率
6.70%
发文量
54
审稿时长
3 months
期刊介绍: Neuroinformatics publishes original articles and reviews with an emphasis on data structure and software tools related to analysis, modeling, integration, and sharing in all areas of neuroscience research. The editors particularly invite contributions on: (1) Theory and methodology, including discussions on ontologies, modeling approaches, database design, and meta-analyses; (2) Descriptions of developed databases and software tools, and of the methods for their distribution; (3) Relevant experimental results, such as reports accompanie by the release of massive data sets; (4) Computational simulations of models integrating and organizing complex data; and (5) Neuroengineering approaches, including hardware, robotics, and information theory studies.
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