环境空气污染物混合物与儿童哮喘加重的联合关系。

IF 3.3 Q2 ENVIRONMENTAL SCIENCES
Jagadeesh Puvvula, Jill A Poole, Sandra Gonzalez, Eleanor G Rogan, Yeongjin Gwon, Andrew C Rorie, Linda B Ford, Jesse E Bell
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引用次数: 4

摘要

已知暴露于空气污染物会加剧哮喘,先前的研究侧重于单一污染物暴露与哮喘恶化之间的关系。由于空气污染物通常以复杂的混合物存在,因此在了解复杂空气污染物混合物与哮喘加重之间的关系方面存在空白。我们评估了空气污染物混合物(52种污染物)与儿童哮喘加重之间的关系。方法:本研究以2016-2019年居住在内布拉斯加州道格拉斯县的儿童(年龄≤19岁)为研究对象。采用广义加权分位数和(qWQS)回归法评估室外空气污染物混合物与儿童哮喘加重相关急诊科(ED)就诊之间的季节尺度联合关联,并进行反复保留验证。结果:我们在春季(滞后5天)、夏季(滞后0-5天)和秋季(滞后1-3天)季节观察到空气污染物混合物与儿童哮喘加重之间的关联。夏季(调整后的-βWQS = 1.11, 95%可信区间[CI]: 0.66, 1.55)、春季(调整后的-βWQS = 0.40, 95% CI: 0.16, 0.62)和秋季(调整后的-βWQS = 0.20, 95% CI: 0.06, 0.33)对室外空气污染物联合混合效应的估计较高。空气污染物中,PM2.5、花粉、霉菌在空气污染物混合物中所占比重较高。结论:春、夏、秋季节室外空气污染物混合物与儿童哮喘发作存在相关性。在调查的52个室外空气污染物指标中,PM2.5、花粉(梧桐、草、雪松)和霉菌(Helminthosporium、Peronospora和Erysiphe)对空气污染物混合物的贡献最大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Joint association between ambient air pollutant mixture and pediatric asthma exacerbations.

Joint association between ambient air pollutant mixture and pediatric asthma exacerbations.

Joint association between ambient air pollutant mixture and pediatric asthma exacerbations.

Exposure to air pollutants is known to exacerbate asthma, with prior studies focused on associations between single pollutant exposure and asthma exacerbations. As air pollutants often exist as a complex mixture, there is a gap in understanding the association between complex air pollutant mixtures and asthma exacerbations. We evaluated the association between the air pollutant mixture (52 pollutants) and pediatric asthma exacerbations.

Method: This study focused on children (age ≤ 19 years) who lived in Douglas County, Nebraska, during 2016-2019. A seasonal-scale joint association between the outdoor air pollutant mixture adjusting for potential confounders (temperature, precipitation, wind speed, and wind direction) in relation to pediatric asthma exacerbation-related emergency department (ED) visits was evaluated using the generalized weighted quantile sum (qWQS) regression with repeated holdout validation.

Results: We observed associations between air pollutant mixture and pediatric asthma exacerbations during spring (lagged by 5 days), summer (lag 0-5 days), and fall (lag 1-3 days) seasons. The estimate of the joint outdoor air pollutant mixture effect was higher during the summer season (adjusted-βWQS = 1.11, 95% confidence interval [CI]: 0.66, 1.55), followed by spring (adjusted-βWQS = 0.40, 95% CI: 0.16, 0.62) and fall (adjusted-βWQS = 0.20, 95% CI: 0.06, 0.33) seasons. Among the air pollutants, PM2.5, pollen, and mold contributed higher weight to the air pollutant mixture.

Conclusion: There were associations between outdoor air pollutant mixture and pediatric asthma exacerbations during the spring, summer, and fall seasons. Among the 52 outdoor air pollutant metrics investigated, PM2.5, pollen (sycamore, grass, cedar), and mold (Helminthosporium, Peronospora, and Erysiphe) contributed the highest weight to the air pollutant mixture.

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来源期刊
Environmental Epidemiology
Environmental Epidemiology Medicine-Public Health, Environmental and Occupational Health
CiteScore
5.70
自引率
2.80%
发文量
71
审稿时长
25 weeks
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