多顺反子microrna的转录后调控。

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Monika Vilimova, Sébastien Pfeffer
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引用次数: 5

摘要

在动物基因组中,一个重要比例的microRNA (miRNA)基因往往彼此靠近。这样的基因组组织通常被称为miRNA集群。尽管已经对许多miRNA簇进行了大量研究,但大多数注意力通常集中在簇miRNA共表达的功能影响上。然而,这些miRNA簇还有另一个引人注目的方面,即它们的多反反性。由于多顺反子mirna在单个RNA前体上转录,因此受益于共同的转录调控,从而使它们能够协调表达。然而,许多报告已经揭示了来自同一簇的成熟mirna积累的惊人差异。事实上,较大的多顺反子转录本可以作为平台,提供不可预见的转录后调控机制,控制单个miRNA加工,从而导致miRNA表达差异,有时甚至挑战多顺反子miRNA共表达的一般假设。在这篇综述中,我们的目的是解决关于miRNA多顺子是如何转录后调控的现有知识。特别是,我们将关注发生在初级转录物水平上的机制,这与个体miRNA加工高度相关,因此对细胞内miRNA功能有直接影响。本文分类如下:RNA加工>小RNA加工>调控RNA /RNAi/核糖开关>效应小RNA的生物发生> RNA与蛋白质和其他分子的相互作用> RNA-蛋白质复合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Post-transcriptional regulation of polycistronic microRNAs.

An important proportion of microRNA (miRNA) genes tend to lie close to each other within animal genomes. Such genomic organization is generally referred to as miRNA clusters. Even though many miRNA clusters have been greatly studied, most attention has been usually focused on functional impacts of clustered miRNA co-expression. However, there is also another compelling aspect about these miRNA clusters, their polycistronic nature. Being transcribed on a single RNA precursor, polycistronic miRNAs benefit from common transcriptional regulation allowing their coordinated expression. And yet, numerous reports have revealed striking discrepancies in the accumulation of mature miRNAs produced from the same cluster. Indeed, the larger polycistronic transcripts can act as platforms providing unforeseen post-transcriptional regulatory mechanisms controlling individual miRNA processing, thus leading to differential miRNA expression, and sometimes even challenging the general assumption that polycistronic miRNAs are co-expressed. In this review, we aim to address the current knowledge about how miRNA polycistrons are post-transcriptionally regulated. In particular, we will focus on the mechanisms occurring at the level of the primary transcript, which are highly relevant for individual miRNA processing and as such have a direct repercussion on miRNA function within the cell. This article is categorized under: RNA Processing > Processing of Small RNAs Regulatory RNAs/RNAi/Riboswitches > Biogenesis of Effector Small RNAs RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes.

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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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