Janina Krell-Roesch, Jeremy A Syrjanen, Jelena Bezold, Sandra Trautwein, Bettina Barisch-Fritz, Walter K Kremers, Julie A Fields, Eugene L Scharf, David S Knopman, Gorazd B Stokin, Ronald C Petersen, Darko Jekauc, Alexander Woll, Maria Vassilaki, Yonas E Geda
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PA (taken as a presumed predictor) in midlife (i.e., when participants were 50-65 years of age) and late life (i.e., the year prior to assessment) was assessed with a self-reported, validated questionnaire; PA intensity and frequency were used to calculate composite scores. NPS (taken as presumed outcomes) were assessed with the Neuropsychiatric Inventory Questionnaire, Beck Depression Inventory (BDI-II), and Beck Anxiety Inventory (BAI). Regression analyses included midlife and late-life PA in each model, which were adjusted for age, sex, education, apolipoprotein E ɛ4 status, and medical comorbidity.</p><p><strong>Results: </strong>Higher late-life PA was associated with lower odds of having apathy (OR=0.89, 95% CI=0.84-0.93), appetite changes (OR=0.92, 95% CI=0.87-0.98), nighttime disturbances (OR=0.95, 95% CI=0.91-0.99), depression (OR=0.94, 95% CI=0.90-0.97), irritability (OR=0.93, 95% CI=0.89-0.97), clinical depression (OR=0.92, 95% CI=0.88-0.97), and clinical anxiety (OR=0.90, 95% CI=0.86-0.94), as well as lower BDI-II (β estimate=-0.042, 95% CI=-0.051 to -0.033) and BAI (β estimate=-0.030, 95% CI=-0.040 to -0.021) scores. Higher midlife PA was associated only with higher BDI-II scores (β estimate=0.011, 95% CI=0.004 to 0.019). Sex modified the associations between PA and NPS.</p><p><strong>Conclusions: </strong>Late-life PA was associated with a lower likelihood of clinical depression or anxiety and subclinical NPS. 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引用次数: 0
摘要
目的:本研究探讨了无痴呆老年人身体活动(PA)与神经精神症状(NPS)之间的关系。方法:这项横断面研究包括3222名≥70岁的个体(1655名男性;平均数±标准差= 79.2±5.6岁;认知未受损,N=2,723;轻度认知障碍,N=499),来自基于人群的梅奥诊所衰老研究。中年(即参与者50-65岁)和晚年(即评估前一年)的PA(作为假定的预测因子)通过自我报告的有效问卷进行评估;PA强度和频率计算综合得分。NPS(作为假定结果)采用神经精神量表、贝克抑郁量表(BDI-II)和贝克焦虑量表(BAI)进行评估。回归分析包括每个模型的中年和晚年PA,并根据年龄、性别、教育程度、载脂蛋白E / 4状态和医疗合并症进行调整。结果:高老年PA与低概率的冷漠(或= 0.89,95% CI -0.93 = 0.84),食欲的变化(或= 0.92,95% CI -0.98 = 0.87),夜间干扰(或= 0.95,95% CI = 0.91 - -0.99)、抑郁(或= 0.94,95% CI -0.97 = 0.90),易怒(或= 0.93,95% CI -0.97 = 0.89),临床抑郁症(或= 0.92,95% CI = 0.88 - -0.97),和临床焦虑(或= 0.90,95% CI -0.94 = 0.86),以及降低BDI-II(估计β= -0.042,95% CI = -0.051 - -0.033)和白(β= -0.030,估计95% CI=-0.040 ~ -0.021)。较高的中年PA仅与较高的BDI-II评分相关(β估计=0.011,95% CI=0.004至0.019)。性别改变了PA和NPS之间的联系。结论:老年PA与临床抑郁或焦虑和亚临床NPS的可能性较低有关。这些发现需要在队列研究中得到证实。
Mid- and Late-Life Physical Activity and Neuropsychiatric Symptoms in Dementia-Free Older Adults: Mayo Clinic Study of Aging.
Objective: This study examined associations between physical activity (PA) and neuropsychiatric symptoms (NPS) in older adults free of dementia.
Methods: This cross-sectional study included 3,222 individuals ≥70 years of age (1,655 men; mean±SD age=79.2±5.6; cognitively unimpaired, N=2,723; mild cognitive impairment, N=499) from the population-based Mayo Clinic Study of Aging. PA (taken as a presumed predictor) in midlife (i.e., when participants were 50-65 years of age) and late life (i.e., the year prior to assessment) was assessed with a self-reported, validated questionnaire; PA intensity and frequency were used to calculate composite scores. NPS (taken as presumed outcomes) were assessed with the Neuropsychiatric Inventory Questionnaire, Beck Depression Inventory (BDI-II), and Beck Anxiety Inventory (BAI). Regression analyses included midlife and late-life PA in each model, which were adjusted for age, sex, education, apolipoprotein E ɛ4 status, and medical comorbidity.
Results: Higher late-life PA was associated with lower odds of having apathy (OR=0.89, 95% CI=0.84-0.93), appetite changes (OR=0.92, 95% CI=0.87-0.98), nighttime disturbances (OR=0.95, 95% CI=0.91-0.99), depression (OR=0.94, 95% CI=0.90-0.97), irritability (OR=0.93, 95% CI=0.89-0.97), clinical depression (OR=0.92, 95% CI=0.88-0.97), and clinical anxiety (OR=0.90, 95% CI=0.86-0.94), as well as lower BDI-II (β estimate=-0.042, 95% CI=-0.051 to -0.033) and BAI (β estimate=-0.030, 95% CI=-0.040 to -0.021) scores. Higher midlife PA was associated only with higher BDI-II scores (β estimate=0.011, 95% CI=0.004 to 0.019). Sex modified the associations between PA and NPS.
Conclusions: Late-life PA was associated with a lower likelihood of clinical depression or anxiety and subclinical NPS. These findings need to be confirmed in a cohort study.
期刊介绍:
As the official Journal of the American Neuropsychiatric Association, the premier North American organization of clinicians, scientists, and educators specializing in behavioral neurology & neuropsychiatry, neuropsychology, and the clinical neurosciences, the Journal of Neuropsychiatry and Clinical Neurosciences (JNCN) aims to publish works that advance the science of brain-behavior relationships, the care of persons and families affected by neurodevelopmental, acquired neurological, and neurodegenerative conditions, and education and training in behavioral neurology & neuropsychiatry. JNCN publishes peer-reviewed articles on the cognitive, emotional, and behavioral manifestations of neurological conditions, the structural and functional neuroanatomy of idiopathic psychiatric disorders, and the clinical and educational applications and public health implications of scientific advances in these areas. The Journal features systematic reviews and meta-analyses, narrative reviews, original research articles, scholarly considerations of treatment and educational challenges in behavioral neurology & neuropsychiatry, analyses and commentaries on advances and emerging trends in the field, international perspectives on neuropsychiatry, opinions and introspections, case reports that inform on the structural and functional bases of neuropsychiatric conditions, and classic pieces from the field’s rich history.