使用分子印迹聚合物接枝碳糊电极的一次性埃多沙班传感器芯片。

IF 1.1 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Journal of Artificial Organs Pub Date : 2024-03-01 Epub Date: 2023-04-15 DOI:10.1007/s10047-023-01392-1
Yasuo Yoshimi, Shohei Kani, Aaryashree
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引用次数: 0

摘要

尽管直接口服抗凝血剂(DOACs)通常是安全的,也不需要TDM,但该药物的血药浓度是急救决策的重要信息。本研究尝试开发一种一次性传感器芯片,用于快速检测血液中的埃多沙班(DOAC 的一种)。以对羟基苯磺酸埃多沙班为模板、对苯乙烯磺酸钠为功能单体的分子印迹聚合物被接枝到石墨颗粒表面,与溶解在二茂铁中的硅油混合成糊状,然后填充到塑料薄膜基底上。传感器芯片制作完成。该传感器在 150 秒内通过伏安法获得的电流取决于埃多沙班的浓度。在牛全血中也证实了对埃多沙班的敏感性。本研究证明了一次性传感器在全血中快速检测埃多沙班的潜力,但其选择性、可重复性和灵敏度还需进一步提高才能投入实际使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A disposable edoxaban sensor chip using carbon paste electrode grafted with molecularly imprinted polymer.

A disposable edoxaban sensor chip using carbon paste electrode grafted with molecularly imprinted polymer.

Although direct oral anticoagulants (DOACs) are generally safe and TDM is not required, blood levels of the drug are important information for response decisions in emergency care. In this study, an attempt was made to develop a disposable sensor chip for the rapid detection of edoxaban in blood, a type of DOAC. Molecularly imprinted polymers with edoxaban tosilate as a template and sodium p-styrene sulfonate as a functional monomer were grafted onto the surface of graphite particles, mixed with silicon oil dissolved in ferrocene to form a paste, and filled onto a substrate made of plastic film. Sensor chips were fabricated. The current obtained from this sensor by voltammetry within 150 s depended on the edoxaban concentration. Sensitivity to edoxaban was also confirmed in bovine whole blood. The potential of disposable sensors to rapidly detect edoxaban in whole blood was demonstrated in this study, although selectivity, reproducibility, and sensitivity need to be improved for practical use.

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来源期刊
Journal of Artificial Organs
Journal of Artificial Organs 医学-工程:生物医学
CiteScore
2.80
自引率
15.40%
发文量
68
审稿时长
6-12 weeks
期刊介绍: The aim of the Journal of Artificial Organs is to introduce to colleagues worldwide a broad spectrum of important new achievements in the field of artificial organs, ranging from fundamental research to clinical applications. The scope of the Journal of Artificial Organs encompasses but is not restricted to blood purification, cardiovascular intervention, biomaterials, and artificial metabolic organs. Additionally, the journal will cover technical and industrial innovations. Membership in the Japanese Society for Artificial Organs is not a prerequisite for submission.
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