突触囊泡易于恢复的池。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Sai Krishnan, Jürgen Klingauf
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引用次数: 1

摘要

在中枢神经系统中,神经元之间的交流发生在突触上,通过突触活性区突触囊泡(SVs)的胞吐分泌神经递质。鉴于突触前钮扣中的SVs数量有限,需要通过触发代偿性内吞作用快速有效地回收胞外膜和蛋白质来维持神经传递。因此,突触前具有独特的外胞和内吞作用在时间和空间上的紧密耦合,导致sv的重组具有统一的形态和明确的分子组成。这种快速反应需要精心安排近活性区早期的内吞作用,以确保sv的高保真度重组。前突触可以通过一个特殊的膜微室来解决这一挑战,在那里形成一个预先分类和预先组装的容易回收的内吞膜斑块池(RRetP),由囊泡货物组成,可能结合在有核网格蛋白和接头复合体内。本综述认为RRetP微室是突触前触发代偿性内吞作用的主要组织者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The readily retrievable pool of synaptic vesicles.

In the CNS communication between neurons occurs at synapses by secretion of neurotransmitter via exocytosis of synaptic vesicles (SVs) at the active zone. Given the limited number of SVs in presynaptic boutons a fast and efficient recycling of exocytosed membrane and proteins by triggered compensatory endocytosis is required to maintain neurotransmission. Thus, pre-synapses feature a unique tight coupling of exo- and endocytosis in time and space resulting in the reformation of SVs with uniform morphology and well-defined molecular composition. This rapid response requires early stages of endocytosis at the peri-active zone to be well choreographed to ensure reformation of SVs with high fidelity. The pre-synapse can address this challenge by a specialized membrane microcompartment, where a pre-sorted and pre-assembled readily retrievable pool (RRetP) of endocytic membrane patches is formed, consisting of the vesicle cargo, presumably bound within a nucleated Clathrin and adaptor complex. This review considers evidence for the RRetP microcompartment to be the primary organizer of presynaptic triggered compensatory endocytosis.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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