Mohammad Kord, Mohammadreza Salehi, Seyed Jamal Hashemi, Alireza Abdollahi, Neda Alijani, Ayda Maleki, Shahram Mahmoudi, Kazem Ahmadikia, Nasrin Parsameher, Masoud Moradi, Mahsa Abdorahimi, Sara Rezaie, Shirin Sadat Hashemi Fesharaki, Kiana Abbasi, Laura Alcazar-Fuoli, Sadegh Khodavaisy
{"title":"念珠菌病患者的临床、流行病学和真菌学特征:伊朗两个三级转诊中心的经验","authors":"Mohammad Kord, Mohammadreza Salehi, Seyed Jamal Hashemi, Alireza Abdollahi, Neda Alijani, Ayda Maleki, Shahram Mahmoudi, Kazem Ahmadikia, Nasrin Parsameher, Masoud Moradi, Mahsa Abdorahimi, Sara Rezaie, Shirin Sadat Hashemi Fesharaki, Kiana Abbasi, Laura Alcazar-Fuoli, Sadegh Khodavaisy","doi":"10.18502/cmm.8.3.11207","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and purpose: </strong>Candidemia is a major cause of morbidity and mortality among patients receiving immunosuppressive therapy and those hospitalized with serious underlying diseases. Here, we investigated the epidemiological, clinical, and mycological features of candidemia in Tehran, Iran.</p><p><strong>Materials and methods: </strong>A prospective observational study of all patients diagnosed with candidemia was performed at two referral teaching hospitals in Tehran, Iran, from February to December 2018. Demographic characteristics, underlying diseases, risk factors, clinical symptoms, and laboratory analyses of candidemic patients with positive culture were mined. <i>Candida</i> isolates were molecularly identified by sequencing of the internal transcribed spacer region (ITS1-5.8S-ITS2). The antifungal susceptibility testing for fluconazole, itraconazole, voriconazole, posaconazole, amphotericin B, caspofungin, micafungin, and anidulafungin against the isolates was performed using CLSI broth microdilution reference method (M27-A3).</p><p><strong>Results: </strong>A total of 89 episodes were identified, with an incidence of 2.1 episodes/1000 admissions. The common underling disease were malignancy (46%), renal failure/dialysis (44%), and hypertension (40%). The overall crude mortality was 47%. <i>C. albicans</i> (44%) was the most frequent causative agent, followed by <i>C. glabrata</i> (21%), <i>C. parapsilosis</i> complex (15%), <i>C. tropicalis</i> (11%), and <i>C. lusitaniae</i> (3.5%). All the isolates were susceptible to amphotericin B. The activity of all four azoles was low against <i>non-albicans Candida</i> species, especially <i>C. tropicalis</i>.</p><p><strong>Conclusion: </strong>The increase in non-<i>albicans Candida</i> species with reduced susceptibility to antifungal drugs might be alarming in high-risk patients. Therefore, accurate knowledge of predisposing factors and epidemiological patterns in candidemia are effective steps for managing and decreasing the mortality rate in candidemia.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"8 3","pages":"9-17"},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084488/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical, epidemiological, and mycological features of patients with candidemia: Experience in two tertiary referral centers in Iran.\",\"authors\":\"Mohammad Kord, Mohammadreza Salehi, Seyed Jamal Hashemi, Alireza Abdollahi, Neda Alijani, Ayda Maleki, Shahram Mahmoudi, Kazem Ahmadikia, Nasrin Parsameher, Masoud Moradi, Mahsa Abdorahimi, Sara Rezaie, Shirin Sadat Hashemi Fesharaki, Kiana Abbasi, Laura Alcazar-Fuoli, Sadegh Khodavaisy\",\"doi\":\"10.18502/cmm.8.3.11207\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and purpose: </strong>Candidemia is a major cause of morbidity and mortality among patients receiving immunosuppressive therapy and those hospitalized with serious underlying diseases. Here, we investigated the epidemiological, clinical, and mycological features of candidemia in Tehran, Iran.</p><p><strong>Materials and methods: </strong>A prospective observational study of all patients diagnosed with candidemia was performed at two referral teaching hospitals in Tehran, Iran, from February to December 2018. Demographic characteristics, underlying diseases, risk factors, clinical symptoms, and laboratory analyses of candidemic patients with positive culture were mined. <i>Candida</i> isolates were molecularly identified by sequencing of the internal transcribed spacer region (ITS1-5.8S-ITS2). The antifungal susceptibility testing for fluconazole, itraconazole, voriconazole, posaconazole, amphotericin B, caspofungin, micafungin, and anidulafungin against the isolates was performed using CLSI broth microdilution reference method (M27-A3).</p><p><strong>Results: </strong>A total of 89 episodes were identified, with an incidence of 2.1 episodes/1000 admissions. The common underling disease were malignancy (46%), renal failure/dialysis (44%), and hypertension (40%). The overall crude mortality was 47%. <i>C. albicans</i> (44%) was the most frequent causative agent, followed by <i>C. glabrata</i> (21%), <i>C. parapsilosis</i> complex (15%), <i>C. tropicalis</i> (11%), and <i>C. lusitaniae</i> (3.5%). All the isolates were susceptible to amphotericin B. The activity of all four azoles was low against <i>non-albicans Candida</i> species, especially <i>C. tropicalis</i>.</p><p><strong>Conclusion: </strong>The increase in non-<i>albicans Candida</i> species with reduced susceptibility to antifungal drugs might be alarming in high-risk patients. Therefore, accurate knowledge of predisposing factors and epidemiological patterns in candidemia are effective steps for managing and decreasing the mortality rate in candidemia.</p>\",\"PeriodicalId\":10863,\"journal\":{\"name\":\"Current Medical Mycology\",\"volume\":\"8 3\",\"pages\":\"9-17\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084488/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Medical Mycology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18502/cmm.8.3.11207\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Medical Mycology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/cmm.8.3.11207","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Clinical, epidemiological, and mycological features of patients with candidemia: Experience in two tertiary referral centers in Iran.
Background and purpose: Candidemia is a major cause of morbidity and mortality among patients receiving immunosuppressive therapy and those hospitalized with serious underlying diseases. Here, we investigated the epidemiological, clinical, and mycological features of candidemia in Tehran, Iran.
Materials and methods: A prospective observational study of all patients diagnosed with candidemia was performed at two referral teaching hospitals in Tehran, Iran, from February to December 2018. Demographic characteristics, underlying diseases, risk factors, clinical symptoms, and laboratory analyses of candidemic patients with positive culture were mined. Candida isolates were molecularly identified by sequencing of the internal transcribed spacer region (ITS1-5.8S-ITS2). The antifungal susceptibility testing for fluconazole, itraconazole, voriconazole, posaconazole, amphotericin B, caspofungin, micafungin, and anidulafungin against the isolates was performed using CLSI broth microdilution reference method (M27-A3).
Results: A total of 89 episodes were identified, with an incidence of 2.1 episodes/1000 admissions. The common underling disease were malignancy (46%), renal failure/dialysis (44%), and hypertension (40%). The overall crude mortality was 47%. C. albicans (44%) was the most frequent causative agent, followed by C. glabrata (21%), C. parapsilosis complex (15%), C. tropicalis (11%), and C. lusitaniae (3.5%). All the isolates were susceptible to amphotericin B. The activity of all four azoles was low against non-albicans Candida species, especially C. tropicalis.
Conclusion: The increase in non-albicans Candida species with reduced susceptibility to antifungal drugs might be alarming in high-risk patients. Therefore, accurate knowledge of predisposing factors and epidemiological patterns in candidemia are effective steps for managing and decreasing the mortality rate in candidemia.
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