健康与疾病中的肺细胞图谱。

IF 15.7 1区 医学 Q1 PHYSIOLOGY
Taylor S Adams, Arnaud Marlier, Naftali Kaminski
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引用次数: 7

摘要

人类肺细胞组合,传统上以细胞形态和个体标记为特征,是高度多样化的,有超过40种细胞类型和复杂的分支结构,高度适应灵活的气流和气体交换。虽然在成年期是不变的,但肺细胞含量会随着暴露、损伤和感染而改变。有些变化是暂时的,但其他变化是持续的,导致结构变化和进行性肺病。单细胞分析技术的最新进展使细胞测量的细节和规模达到了前所未有的水平,从而导致了综合细胞图谱报告风格的兴起。在这篇综述中,我们记录了细胞图谱的兴起,并探讨了它们在健康和疾病方面对人类肺生物学的贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lung Cell Atlases in Health and Disease.

The human lung cellular portfolio, traditionally characterized by cellular morphology and individual markers, is highly diverse, with over 40 cell types and a complex branching structure highly adapted for agile airflow and gas exchange. While constant during adulthood, lung cellular content changes in response to exposure, injury, and infection. Some changes are temporary, but others are persistent, leading to structural changes and progressive lung disease. The recent advance of single-cell profiling technologies allows an unprecedented level of detail and scale to cellular measurements, leading to the rise of comprehensive cell atlas styles of reporting. In this review, we chronical the rise of cell atlases and explore their contributions to human lung biology in health and disease.

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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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