伊朗伊斯法罕重症监护病房念珠菌的流行病学、种类分布、抗真菌敏感性和结果

Q3 Medicine
Azam Haghighatfard, Saeed Abbasi, Pegah Alijani, Farzaneh Afyooni Akbari, Hossein Rashidi, Parvin Dehghan
{"title":"伊朗伊斯法罕重症监护病房念珠菌的流行病学、种类分布、抗真菌敏感性和结果","authors":"Azam Haghighatfard,&nbsp;Saeed Abbasi,&nbsp;Pegah Alijani,&nbsp;Farzaneh Afyooni Akbari,&nbsp;Hossein Rashidi,&nbsp;Parvin Dehghan","doi":"10.18502/cmm.8.3.11217","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and purpose: </strong>Candidemia is known as an invasive fungal infection with high mortality. The prevalence of candidemia in intensive care unit (ICU) patients is more than in other hospital wards. Early diagnosis of candidemia in these patients is essential for disease management.</p><p><strong>Materials and methods: </strong>This study included 250 patients suspected of candidemia. Blood samples were taken from patients and incubated. The fungal isolates were identified by PCR-RFLP method using <i>MSP I</i> restriction enzyme. Demographic characteristics, risk factors, underlying diseases, and laboratory analysis results were mined in this study.</p><p><strong>Results: </strong>In total, 22 blood samples were identified as positive for <i>Candida</i> yeasts in culture. The most common underlying diseases in these patients were heart disease and hypertension (36.4%). <i>Candida albicans</i> with 12 cases (54.5%) was the most isolated species, followed by <i>C. parapsilosis</i> (n=5, 22.7%), <i>C. glabrata</i> (n=4, 18.2%), and <i>C. tropicalis</i> (n=1, 4.5%) in descending order. Intravenous catheter use was recognized as the most common risk factor in patients with candidemia (77.3%), and after that, the use of mechanical ventilation (68.2%) and urinary catheter (40.9%) obtained the highest frequency. Furthermore, 17 patients were prescribed at least one antifungal drug, of which fluconazole was the most used (36.4%). The mortality rate in patients in this study was 63.6%. All <i>C. albicans</i> isolates were susceptible to antifungal agents but in non-<i>albicans Candida</i> (NAC), drug resistance to fluconazole, voriconazole, and caspofungin were observed.</p><p><strong>Conclusion: </strong>Although <i>C. albicans</i> was the most common fungal species in this study, the prevalence of NAC species was high. The increasing frequency of NAC species is a concern because they have different patterns of drug resistance. Recognition of risk factors in patients admitted to ICUs can help prevent candidemia or properly manage the disease.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"8 3","pages":"30-34"},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084487/pdf/","citationCount":"1","resultStr":"{\"title\":\"Epidemiology, species distribution, antifungal susceptibility, and outcome of candidemia in intensive care units in Isfahan, Iran.\",\"authors\":\"Azam Haghighatfard,&nbsp;Saeed Abbasi,&nbsp;Pegah Alijani,&nbsp;Farzaneh Afyooni Akbari,&nbsp;Hossein Rashidi,&nbsp;Parvin Dehghan\",\"doi\":\"10.18502/cmm.8.3.11217\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and purpose: </strong>Candidemia is known as an invasive fungal infection with high mortality. The prevalence of candidemia in intensive care unit (ICU) patients is more than in other hospital wards. Early diagnosis of candidemia in these patients is essential for disease management.</p><p><strong>Materials and methods: </strong>This study included 250 patients suspected of candidemia. Blood samples were taken from patients and incubated. The fungal isolates were identified by PCR-RFLP method using <i>MSP I</i> restriction enzyme. Demographic characteristics, risk factors, underlying diseases, and laboratory analysis results were mined in this study.</p><p><strong>Results: </strong>In total, 22 blood samples were identified as positive for <i>Candida</i> yeasts in culture. The most common underlying diseases in these patients were heart disease and hypertension (36.4%). <i>Candida albicans</i> with 12 cases (54.5%) was the most isolated species, followed by <i>C. parapsilosis</i> (n=5, 22.7%), <i>C. glabrata</i> (n=4, 18.2%), and <i>C. tropicalis</i> (n=1, 4.5%) in descending order. Intravenous catheter use was recognized as the most common risk factor in patients with candidemia (77.3%), and after that, the use of mechanical ventilation (68.2%) and urinary catheter (40.9%) obtained the highest frequency. Furthermore, 17 patients were prescribed at least one antifungal drug, of which fluconazole was the most used (36.4%). The mortality rate in patients in this study was 63.6%. All <i>C. albicans</i> isolates were susceptible to antifungal agents but in non-<i>albicans Candida</i> (NAC), drug resistance to fluconazole, voriconazole, and caspofungin were observed.</p><p><strong>Conclusion: </strong>Although <i>C. albicans</i> was the most common fungal species in this study, the prevalence of NAC species was high. The increasing frequency of NAC species is a concern because they have different patterns of drug resistance. Recognition of risk factors in patients admitted to ICUs can help prevent candidemia or properly manage the disease.</p>\",\"PeriodicalId\":10863,\"journal\":{\"name\":\"Current Medical Mycology\",\"volume\":\"8 3\",\"pages\":\"30-34\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084487/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Medical Mycology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18502/cmm.8.3.11217\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Medical Mycology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/cmm.8.3.11217","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 1

摘要

背景与目的:念珠菌是一种具有高致死率的侵袭性真菌感染。在重症监护病房(ICU)患者中念珠菌的患病率高于其他医院病房。这些患者的念珠菌病的早期诊断对疾病管理至关重要。材料与方法:本研究纳入250例疑似念珠菌病患者。从患者身上采集血样并进行孵育。采用MSP - I限制性内切酶对分离菌株进行PCR-RFLP鉴定。人口统计学特征、危险因素、潜在疾病和实验室分析结果在本研究中被挖掘。结果:共有22份血液样本在培养中被鉴定为念珠菌阳性。这些患者最常见的基础疾病是心脏病和高血压(36.4%)。分离最多的菌种为白色念珠菌(12例,占54.5%),其次为假丝酵母菌(n=5,占22.7%)、光丝酵母菌(n=4,占18.2%)和热带念珠菌(n=1,占4.5%)。静脉置管是念珠菌病患者最常见的危险因素(77.3%),其次是机械通气(68.2%)和导尿管(40.9%)。此外,17例患者至少使用了一种抗真菌药物,其中氟康唑使用最多(36.4%)。本组患者死亡率为63.6%。所有白色念珠菌分离株均对抗真菌药物敏感,而非白色念珠菌(NAC)对氟康唑、伏立康唑和卡泊芬净均有耐药性。结论:虽然白色念珠菌是本研究中最常见的真菌种类,但NAC种类的患病率较高。NAC物种出现频率的增加令人担忧,因为它们具有不同的耐药模式。识别icu患者的危险因素有助于预防念珠菌血症或正确管理疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiology, species distribution, antifungal susceptibility, and outcome of candidemia in intensive care units in Isfahan, Iran.

Background and purpose: Candidemia is known as an invasive fungal infection with high mortality. The prevalence of candidemia in intensive care unit (ICU) patients is more than in other hospital wards. Early diagnosis of candidemia in these patients is essential for disease management.

Materials and methods: This study included 250 patients suspected of candidemia. Blood samples were taken from patients and incubated. The fungal isolates were identified by PCR-RFLP method using MSP I restriction enzyme. Demographic characteristics, risk factors, underlying diseases, and laboratory analysis results were mined in this study.

Results: In total, 22 blood samples were identified as positive for Candida yeasts in culture. The most common underlying diseases in these patients were heart disease and hypertension (36.4%). Candida albicans with 12 cases (54.5%) was the most isolated species, followed by C. parapsilosis (n=5, 22.7%), C. glabrata (n=4, 18.2%), and C. tropicalis (n=1, 4.5%) in descending order. Intravenous catheter use was recognized as the most common risk factor in patients with candidemia (77.3%), and after that, the use of mechanical ventilation (68.2%) and urinary catheter (40.9%) obtained the highest frequency. Furthermore, 17 patients were prescribed at least one antifungal drug, of which fluconazole was the most used (36.4%). The mortality rate in patients in this study was 63.6%. All C. albicans isolates were susceptible to antifungal agents but in non-albicans Candida (NAC), drug resistance to fluconazole, voriconazole, and caspofungin were observed.

Conclusion: Although C. albicans was the most common fungal species in this study, the prevalence of NAC species was high. The increasing frequency of NAC species is a concern because they have different patterns of drug resistance. Recognition of risk factors in patients admitted to ICUs can help prevent candidemia or properly manage the disease.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Current Medical Mycology
Current Medical Mycology Medicine-Infectious Diseases
CiteScore
2.10
自引率
0.00%
发文量
16
审稿时长
4 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信